Welcome to the Precision Medicine Podcast by Trapelo. Created and hosted by patient advocate Karan Cushman, this is the podcast where leading voices in cancer explore how to bring precision medicine to patients everywhere.
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Welcome to the “Precision Medicine Made Simple Podcast,” where we simplify the complex world of precision medicine. We're here to explore how personalized healthcare can empower you to understand and improve your health to live a longer and healthier life. Join us as we break down the latest in medical science into actionable insights. Let's make precision medicine accessible and actionable for everyone. Sponsored by: Biography Health, where healthcare meets personalization. With their DNAbl ...
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Welcome to the Talking Precision Medicine podcast. In this series, we sit down with experts on the application of AI and big data analytics in the drug discovery space. Our guests are innovators, business decision makers and thought leaders at the intersection of data and therapeutics. We discuss the promise, practice, challenges, and myths of AI in precision medicine. This show is brought to you by Genialis, and Rafael, our CEO, is your host.
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The Pursuit of Precision: The Science Advancing Individualized Medicine
Mayo Clinic Center for Individualized Medicine
This podcast series focuses on in-depth conversations with researchers and physicians on discoveries and emerging science in precision medicine. Each episode features lively discussion between a Mayo Clinic colleague and guest from an external institution. We welcome your questions and comments, please email us at [email protected]
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Sleep, HRV & Longevity: What Your Data Really Means with Dr. Mohammad Jarbou
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44:26In this episode of Precision Medicine Made Simple, we continue our discussion with Dr. Mohammad Jarbou from Episode 33, where we first explored the significance of VO₂ Max testing and its role in personal health optimization. Now, we dive deeper into the importance of sleep health, heart rate variability (HRV), and the insights provided by sleep st…
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Liquid Biopsy for Precision Medicine: What’s Actionable Now and What’s Next
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28:47Advances in molecular diagnostics are reshaping how cancer is detected, monitored, and treated, and liquid biopsy is becoming central to that progress. This simple blood draw can reveal key tumor biology at diagnosis and over time, providing timely insight and guiding more precise decisions throughout a patient’s journey. Clinicians now face an imp…
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Michelle Chen | Using AI to derisk gene therapy and genetic medicine | TPM podcast #51
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36:27In this episode Rafael sits down with Michelle Chen, President and CEO of Form Bio, a techbio company using AI to advance genome engineering and the development of genetic medicines. Michelle shares her zigzag journey from scientist to executive, how her team is tackling the biggest bottlenecks in gene therapy, and why AI has become essential in de…
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Inside the Membership Model That’s Making Healthcare Personal Again
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58:30The traditional healthcare system is breaking under the weight of burnout, short appointments, and profit-driven incentives, and Dr. Adam Wheeler has lived it from the inside. After losing a patient and realizing that all his creative energy was going into improving metrics instead of improving lives, he decided to build something radically differe…
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Mike Rossi, ConcertAI | Real world data and artificial intelligence turn anecdote to evidence | TPM podcast #50
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44:44Today I’m joined by Mike Rossi, Vice President of Translational Science and Multi-modal Real-World Evidence Solutions at ConcertAI. Mike has built a career at the intersection of genomics, data science, and oncology, helping to bridge the gap between research and real-world clinical practice. We talk about what real-world data really means, how it …
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Optimizing Health Span: How Fitness, Sleep, and Genetics Shape Longevity
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1:23:41In this episode of Precision Medicine Made Simple, we’re joined by Dr. Mohammad Jarbou, co-founder of the Longevity Clinic. Dr. Jarbou, a board-certified physician in pulmonary medicine, critical care, sleep medicine, and clinical informatics, discusses how his clinic uses a holistic approach to aging and health span. The clinic focuses on preventi…
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Understanding Polygenic Risk Scores: A Deep Dive into Genetics and Predictive Healthcare
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53:40In this episode of Precision Medicine Made Simple, we’re joined by Dr. Jeff Gulcher, co-founder of Decode Genetics and current leader at Galateo Bio. Dr. Gulcher shares his vast experience in the field of genomics and precision medicine, covering everything from polygenic risk scores (PRS) to the challenges of integrating diverse genetic data into …
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Navigating Healthcare Complexity: DIY Testing, AI, and Building Your Trusted Care Team
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41:52In this episode of Precision Medicine Made Simple, we’re joined by Lucy Janoyan, the Chief Operations Officer and Chief Strategy Officer at Biography Health. Together with Taylor Cu, Lucy dives into a wide-ranging discussion on the state of healthcare, DIY testing, and the future of personalized care. Lucy and Taylor reflect on their experience at …
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Liquid Biopsy Part 1: Breaking Speed and Access Barriers in Precision Oncology
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34:46Liquid biopsy is breaking speed and access barriers in precision oncology. In this episode of the Precision Medicine Podcast, part of our series Bringing Precision Medicine to Everyone and the first in a two-part focus, founder and host Karan Cushman speaks with Dr. Kashyap Patel, CEO of Carolina Blood and Cancer Care Associates, author, and nation…
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Polygenic Risk Scores 101: A Key to Predicting and Preventing Complex Diseases
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36:53In this episode of Precision Medicine Made Simple, we welcome back Dr. Yelena Bykhovskaya, the Chief Scientific Officer at Biography Health, for a deep dive into polygenic risk scores (PRS) and their emerging role in precision medicine. Dr. Bykhovskaya breaks down the complexities of genetics and its application in clinical practice, focusing on ho…
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Mida Pezeshkian, Stema_cg | Launching products in healthcare: The most important framework is flexibility | TPM podcast #49
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44:30Joining us on this episode is Mida Pezeshkian, an old colleague and friend. Mida’s career has spanned from the depths of stem cell science as a student to her current focus on product management in healthcare. We talk about what it really takes to launch products in this space, and how she helps customers bring truly transformational innovations to…
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Why Performance Medicine Matters More Than Prevention
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1:01:49In this episode of Precision Medicine Made Simple, we’re joined by Dr. Rich Joseph, a physician with a rare blend of expertise as both a strength and conditioning specialist and a competitive athlete. Dr. Joseph is the founder of VIM Medicine and the Board Chair of Vital Connections. He’s also a faculty member at Harvard Medical School and Brigham …
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7 Paradigm Shifts That Will Rewrite Medicine
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1:00:17Most of today’s healthcare still treats problems after they happen. Dr. Leroy Hood thinks that needs to change. In this episode of Precision Medicine Made Simple, he explains how genomics, regular health tracking, and AI can shift the focus to preventing disease before it starts. Dr. Hood is one of the scientists who helped build the automated DNA …
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The Osteopathic Doctor Who Maps Your Genetics, Mental Health, and Body Systems
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57:48What does it really take to solve the medical mysteries most doctors dismiss? In this episode of Precision Medicine Made Simple, we sit down with Dr. Hengameh Monsef, DO, an internal medicine physician trained in high-acuity care, now reinventing how we treat chronic and complex illness through concierge precision medicine at Ascending Medicine. Sh…
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Michael Montalto, Amgen | How to have the biggest impact on patients: a career of invention, innovation, and implementation | TPM podcast #48
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43:24Today on the show, I’m joined by Michael Montalto, vice president of precision medicine at Amgen. Amgen is widely recognized as one of the most successful pharmaceutical companies in translating research and development into approved therapies. A key part of that success comes from their focus on precision medicine, and Mike brings a unique perspec…
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The Hardest Part of Longevity Medicine According to This Stanford Doctor
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1:03:51What if your doctor could predict what will kill you—before it ever becomes a problem? In this episode of Precision Medicine Made Simple, we dive into the evolving landscape of longevity medicine and health AI with Dr. Hillary Lin, Stanford-trained internist, former oncologist, and co-founder of CareCore—a platform empowering wellness creators and …
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Bringing Precision Medicine—and Compassion—to Every Cancer Journey with Dr. Arif Kamal
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59:42What does it really mean to bring precision medicine to every patient, in every community? In this inspiring, one-hour episode of the Precision Medicine Podcast, host Karan Cushman sits down with Dr. Arif Kamal, Chief Patient Officer at the American Cancer Society (ACS), for a wide-ranging conversation that reframes how we think about progress in c…
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The Side of Personalized Healthcare No One Talks About
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53:19In this episode of Precision Medicine Made Simple, hosts Dr. William Stanford and Taylor Cu sit down with Dr. Genise Fraiman, founder of Ascending Medicine and a trailblazer in concierge care. With over two decades of experience—from co-founding one of Cedars-Sinai’s top hospitalist groups to mentoring young physicians—Dr. Fraiman shares her person…
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Tom Neyarapally, Archetype Therapeutics | A new paradigm for generative AI drug discovery: more accurate shots on a much wider goal | TPM podcast #47
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42:43Joining us on this episode is Tom Neyarapally, co-founder and CEO of Archetype Therapeutics, an exciting new AI-driven company in the drug discovery space. Archetype is an AI-native biotech pioneering the use of generative chemogenomics and patient clinicogenomic data to virtually screen billions of potential drug candidates each day. TPM E47 hig…
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This Ex-Surgeon Is Reprogramming Aging with AI and Systems Science
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53:29We’re living in the age of health data overload—but how do you turn all those insights into real-life transformation? This episode of Precision Medicine Made Simple features Dr. Daniel Stickler, former vascular surgeon turned systems medicine pioneer, who’s leading the charge in longevity, AI-powered diagnostics, and cutting-edge clinical tools. In…
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The Former ER Doctor Challenging How We Practice Medicine w/Dr. Sukhjit "Sarge" Takhar
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1:16:33The Former ER Doctor Challenging How We Practice Medicine w/Dr. Sukhjit "Sarge" Takhar Primary-MD.com Email: [email protected] Takeaways Dr. Takhar emphasizes the importance of understanding the patient as a person. Concierge medicine allows for more personalized and attentive care. The healthcare system often limits the time doctors can spen…
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Inherited Cancer Risk: What Every Patient and Clinician Needs to Know with Guest Ellen Matloff
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44:31When patients understand their inherited risk for cancer, they’re empowered to take action—often before cancer has a chance to take hold. In this second episode of our Bringing Precision Medicine to Every Patient series, host Karan Cushman is joined by two trusted experts, Ellen Matloff and Dr. Angella Charnot-Katsikas. Together, they provide clear…
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The Doctor Who Says Dialysis Is Preventable w/ Dr. David Moskowitz
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1:08:53In this episode, Dr. David Moskowitz shares how thousands of patients have avoided dialysis through genomic medicine — and why most kidney failure is preventable. We dive deep into ACE genes, repurposed drugs like quinapril and ProGraph, and explore what genomic insights could mean for diseases like Alzheimer's and cancer. Heads up: this one gets d…
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Stéphane Budel, DeciBio | Precision medicine is our future and our fate | TPM podcast #46
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50:02Stéphane Budel, founding partner at DeciBio, joins the Talking Precision Medicine Podcast to explore the future of the field. He unpacks how liquid biopsy, multi-omics, and AI are opening new doors for personalized care, why the diagnostics business model is holding innovation back, and what it will take to make complex tech usable for clinicians a…
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What Jensen Huang Got Right About the Future of Healthcare w/Lucy Janoyan
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57:50In this episode, Dr. Stanford, Lucy Janoyan, and Taylor Cu reflect on key takeaways from the Precision Medicine World Conference — from AI’s role in understanding disease to the future of polygenic risk scores. They discuss the challenges of data validity, patient privacy, and the evolving role of patients and providers in a tech-driven healthcare …
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New Series: Bringing Precision Medicine to Everyone with Dr. Kashyap Patel + Dr. Angella Charnot-Katsikas
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34:12In Episode 66 of the Precision Medicine Podcast, host Karan Cushman kicks off a vital new series, Bringing Precision Medicine to Everyone in collaboration with Dr. Kashyap Patel, a nationally respected community oncologist and founder of the No One Left Alone initiative. This series explores what it takes to close the gap between innovation and acc…
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Anna Berkenblit & Sudheer Doss, PanCAN | On a mission to beat an ignoble killer: pancreatic cancer | TPM podcast #45
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46:10Today’s guests are Anna Berkenblit, Chief Scientific and Medical Officer at the Pancreatic Cancer Action Network, and Sudheer Doss, Chief Business Officer at PanCAN. The Pancreatic Cancer Action Network is the leading organization dedicated to advancing progress against pancreatic cancer. It empowers patients and caregivers, drives early detection …
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Najat Khan | Radical Transformation: Becoming a Medicines Company with End-to-End AI | TPM #44
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38:35Today’s guest is Najat Khan, Chief R&D Officer and Chief Commercial Officer at Recursion Pharmaceuticals. Recursion is widely recognized as one of the most visible—and so far, most successful—companies to emerge from the tech-bio movement. Many consider it the current industry leader. It has become an iconic name in the field of artificial intellig…
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How AI is Revolutionizing Precision Medicine: Dr. Douglas Flora & Dr. Sanjay Juneja on the Future of Cancer Care
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50:02In this episode of the Precision Medicine Podcast, host Karan Cushman engages in a thought-provoking discussion with two pioneers in AI-driven oncology: Dr. Douglas Flora and Dr. Sanjay Juneja. Together, they explore how AI is revolutionizing cancer care, from earlier detection and faster diagnoses to personalized treatments and clinical trial opti…
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Ryan Fukushima | Reinventing diagnostics: The superpower of not knowing what can’t be done | TPM #43
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43:19What a pleasure to welcome today’s guest, Ryan Fukushima, chief operating officer of TempusAI. Not only has Ryan helped build Tempus brick by brick from the earliest days, he is also CEO of Pathos AI, a biotech company using real world data and AI to develop true precision medicines. I don’t know how he juggles it all, but unless you’ve been hiding…
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The journey to the top of life sciences technology: a lifetime of listening and learning | Talking Precision Medicine #42
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47:34Today my guest is Joydeep Goswami, newly appointed President and CEO of the storied biotechnology company LGC. Joydeep is also a strategy advisor to Genialis. Join us as we discuss his remarkable career and lessons learned at each step of the way. Come on in and have a listen. Episode 42 links: TPM E42 for highlights and links from this e…
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Podcast Suggestion SurveyAutor: Taylor Cu
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Advancing Prostate Cancer Care with Dr. William Oh: Precision Medicine, Diagnostics and Advocacy (Part 2)
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32:41In this two-part episode of the Precision Medicine Podcast, host Karan Cushman continues her deep dive into prostate cancer care with expert guest Dr. William Oh, a leading genitourinary oncologist, Director of Precision Medicine at Yale Cancer Center and Chair of the American Cancer Society National Prostate Cancer Roundtable. Building on part one…
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When Genes Collide: A Rare Diagnosis Reveals Complex Health Interactions with Dr. Philip Bretsky
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1:24:43When Genes Collide: A Rare Diagnosis Reveals Complex Health Interactions with Dr. Philip Bretsky For this episode, Dr. Bretsky shares a remarkable case study that unravels the complex relationship between genes and inflammation. When a patient's mysterious symptoms led to the rare diagnosis of VEXAS syndrome, it revealed an unexpected connection wi…
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The view from 30,000: Healthcare & life science AI in the cloud | Talking Precision Medicine #41
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37:10This episode features a conversation with Shweta Maniar, who leads the Healthcare and Life Science effort at Google cloud. In just a few short years, artificial intelligence has gone from the stuff of hype and fairy tale to powerful and ubiquitous tools for all aspects of R&D and healthcare delivery. Google has been central to this sea change. I di…
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Beauty Span and Health Span: Where Aesthetics Meets Longevity with Dr. Cory Goldberg
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1:32:46Beauty Span and Health Span: Where Aesthetics Meets Longevity with Dr. Cory Goldberg For this episode, we dive deep into the intersection of aesthetics and longevity with Dr. Cory Goldberg, a renowned plastic and craniofacial surgeon. Dr. Goldberg bridges the art of aesthetic medicine with the science of precision medicine, sharing groundbreaking i…
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Dr. William Oh on How Precision Medicine and Early Detection Transform Outcomes in Prostate Cancer Care (Part 1)
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41:38In part one of a two-part series on prostate cancer, the Precision Medicine Podcast addresses critical challenges as well as new advancements in prostate cancer, the second leading cause of cancer-related deaths in men. Host, Karan Cushman, is joined by Dr. William Oh, Director of Precision Medicine at Yale Cancer Center and Chair of the American C…
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From Flight Medic to Precision Medicine with Dr. Kat Schmolly
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1:02:47From Flight Medic to Precision Medicine with Dr. Kat Schmolly In this episode, we're joined by Dr. Kat Schmolly. From her adventurous past as an Air Force Flight Medic to her current mission revolutionizing rare disease diagnosis, Dr. Schmolly shares her unique journey into precision medicine. We discuss why bringing personalized care to the frontl…
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A Doctor's Mission: How Dr. Scoles Used Genetics to Transform Patient Care with Dr. Lyndell Scoles
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55:22A Doctor's Mission: How Dr. Scoles Used Genetics to Transform Patient Care with Dr. Lyndell Scoles In this episode, we explore pharmacogenomics, also known as genetic pharmaceutical profiling with Dr. Lyndell Scoles with MDVIP. He’s an early pioneer in using genetic testing to optimize medication choices. With over 30 years of experience in interna…
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What’s in a digital twin? Inventing new kinds of AI for biomedicine | Talking Precision Medicine #40
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47:02Our guest this episode is Charles Fisher, co-founder and currently Chief Scientific Officer of Unlearn.AI. Unlearn has been a leader in the advancement of Digital Twins as a tool to drastically improve the efficiency of clinical trials. Not only a visionary scientist and trailblazing entrepreneur, Charles is fearless with his hot takes. So sit back…
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Beyond One-Size-Fits-All: The Science of Drug-Gene Interactions with Michelle Beckwith
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1:14:11Ep. 15 - Beyond One-Size-Fits-All: The Science of Drug-Gene Interactions with Michelle Beckwith This episode features Michelle "Shelly" Beckwith, a genetics pioneer since the 1990s who worked on the Human Genome Project. She breaks down how pharmacogenetic testing helps optimize medication choices by analyzing how patients' genetic variations affec…
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Genotyping vs. Sequencing: What's the Difference? with Yelena Bykhovskaya, PhD
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27:05Genotyping vs. Sequencing: What's the Difference? In this episode, Dr. William Stanford, Dr. Yelena Bykhovskaya and Taylor Cu discuss various genetic testing methods. The conversation compares genotyping, exome sequencing, and whole genome sequencing, with an emphasis on whole genome sequencing, which provides the most comprehensive genetic informa…
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Leave No Patient Behind—R&D Tools and Cutting Edge Diagnostics that Span the Globe | Talking Precision Medicine #39
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35:38What a genuine pleasure to sit with Thierry Bernard, CEO of Qiagen. As I told Thierry, Qiagen is a truly iconic brand for anyone who came up through molecular biology laboratories in the past 30 years. Their products were ubiquitous, and crucial, to the success of our research. In this conversation, Thierry talks about his global vision for precisi…
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Bridging the Gap: Scientists and Physicians in Precision Medicine with Yelena Bykhovskaya, PhD
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1:15:41In this episode, Dr. Yelena Bykhovskaya, Chief Scientific Officer at Biography Health, shares her expertise in genetics. We explore the importance of both polygenic and monogenic risk scores in patient care. The conversation underscores the value of combining cutting-edge genetic analysis with traditional clinical factors in the evolving field of p…
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How Doctors are Using Genetic Data to Transform Patient Care with Philip Bretsky MD PhD MPH FACP
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58:33How Doctors are Using Genetic Data to Transform Patient Care with Philip Bretsky MD PhD MPH FACP In this episode, we're joined by Dr. Philip Bretsky, a board-certified internist from Santa Monica with expertise in epidemiology and Alzheimer's research. Dr. Bretsky discusses how precision medicine is transforming healthcare by integrating genetics, …
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New Legislation Helps Deliver Appropriate Biomarker Testing to More Cancer Patients When and Where They Need It
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37:43New Legislation Helps Deliver Appropriate Biomarker Testing to More Cancer Patients When and Where They Need It Currently, there is a significant divide between the promise of precision medicine and how equitably new innovations are applied to each cancer patient’s treatment journey. Our expert guests Hilary Gee Goeckner (Director of State and Loca…
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Redefining the Healthcare Model: Insights from 20-Year Executive Lucy Janoyan
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1:20:52Redefining the Healthcare Model: Insights from 20-Year Executive Lucy Janoyan In this episode, we're joined by special guest Lucy Janoyan, Chief Strategy Officer at Biography Health. With over two decades of healthcare executive experience, Lucy explores the transition from reactive to proactive healthcare. She discusses the challenges facing prima…
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Zola-007: Giving T-cells the license to kill | Talking Precision Medicine #38
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44:06What a pleasure to sit down with my long time colleague and friend, Art Krieg, to discuss his latest venture, Zola Therapeutics, and his adventures in the great outdoors. Art has launched and exited a number of innovative biotechs, each time delving deeper into mechanisms by which we can harness the immune system for therapeutic purposes. Join us a…
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Gen Z Takes Action: The Preventive Health Shift
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1:06:58Gen Z Takes Action: The Preventive Health Shift In this episode, we're joined by two younger guests for our Gen Z special featuring Eliana Stanford, Dr. Stanford's daughter, and Lexie Horizon, whose parents are fellow doctors and friends of Dr. Stanford, and who recently interned at Biography Health. This unique conversation explores why younger ge…
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Taylor Can't Outrun His Genetics: Lipid Panel Reality Check
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56:50Taylor Can't Outrun His Genetics: Lipid Panel Reality Check In this episode, Dr. Stanford and I uncover surprising truths from my advanced lipid panel. Despite my active lifestyle, the results reveal hidden risks for heart disease and diabetes. We explore how genetic factors and subtle imbalances can impact long-term health, and discuss targeted in…
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