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Alan Green MD: Rapamycin for Longevity in Clinical Practice

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Manage episode 302137408 series 2981357
Treść dostarczona przez Robert Lufkin MD. Cała zawartość podcastów, w tym odcinki, grafika i opisy podcastów, jest przesyłana i udostępniana bezpośrednio przez Robert Lufkin MD lub jego partnera na platformie podcastów. Jeśli uważasz, że ktoś wykorzystuje Twoje dzieło chronione prawem autorskim bez Twojej zgody, możesz postępować zgodnie z procedurą opisaną tutaj https://pl.player.fm/legal.

#008-The physician with arguably the largest clinical experience in prescribing Rapamycin for longevity talks about the challenges and benefits of this fascinating and controversial practice. Dr Alan Green takes us on a deep dive on the use of Rapamycin for longevity.
Take away points:
-Rapamycin has extended the lifespan of organisms from yeast, worms, flies, and even middle-aged mice.
-In a 2014 paper, rapamycin extended the median lifespan 23% in male mice and 26% in female mice.
-It is an FDA approved prescription drug with indications for use for the prevention of organ transplant rejection and for the treatment of lymphangioleiomyomatosis.
-The drug requires a prescription and should only be used under supervision of a physician
-Rapamycin acts by suppressing the master nutrient sensing protein mTOR [mechanistic target of Rapamycin]
02:45 Blagosklonny papers (Blagosklonny 2019)
05:23 Jane Mannick rapalogue paper (Mannick 2014)
08:04 Cardiomyopathy diagnosis : Apical hypertrophic cardiomyopathy
09:14 Elevated mTOR as common factor- Inflammation, fibrosis,
12:03 Rapamycin role to decrease mTOR overview common pathway
14:23 mTOR is essentially command and control of the cell for the last 2 billion years
15:00 Mitochondrial complex 1 affected by common pathway by rapamycin, caloric restriction, protein restriction, methionine restriction has universal anti-aging effects
16:05 Increased mTOR causes increased innate immune system/inflammation
17:28 2009 paper showed increased mouse lifespan not by just decreasing cancer but most other diseases of aging
19:15 Osteoarthritis inflammation improved by decreased mTOR and increased autophagy
23:00 Alzheimer disease as a disease of senescent cells
26:00 importance of dose timing for Rapamycin
27:00 Anti aging effects on mTOR1 and other effects on mTOR2
32:00 Rapamycin as off patent drug
37:00 Dosing considerations and subjective effects
40:00 Tracking HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) score
42:00 Improvement in exercise related to maximum cardiac output
45:00 Age associated cardiomyopathy
49:00 Untoward effects- Aphthous ulcers and decreased innate immune system. Be on guard for bacterial infections.
57:00 Personal lifestyle choices
https://rapamycintherapy.com/
Rapamycin Clinical Registry
https://www.rapamycin.io/
Bl

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*** SPONSORSHIPS & BRANDS ***
We do work with sponsors and brands. If you are interested in working with us for your health industry product or service, please contact us at: https://www.robertlufkinmd.com/contact/
NOTE:
This is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have. Never disregard professional medical advice or delay in seeking it becaus...

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147 odcinków

Artwork
iconUdostępnij
 
Manage episode 302137408 series 2981357
Treść dostarczona przez Robert Lufkin MD. Cała zawartość podcastów, w tym odcinki, grafika i opisy podcastów, jest przesyłana i udostępniana bezpośrednio przez Robert Lufkin MD lub jego partnera na platformie podcastów. Jeśli uważasz, że ktoś wykorzystuje Twoje dzieło chronione prawem autorskim bez Twojej zgody, możesz postępować zgodnie z procedurą opisaną tutaj https://pl.player.fm/legal.

#008-The physician with arguably the largest clinical experience in prescribing Rapamycin for longevity talks about the challenges and benefits of this fascinating and controversial practice. Dr Alan Green takes us on a deep dive on the use of Rapamycin for longevity.
Take away points:
-Rapamycin has extended the lifespan of organisms from yeast, worms, flies, and even middle-aged mice.
-In a 2014 paper, rapamycin extended the median lifespan 23% in male mice and 26% in female mice.
-It is an FDA approved prescription drug with indications for use for the prevention of organ transplant rejection and for the treatment of lymphangioleiomyomatosis.
-The drug requires a prescription and should only be used under supervision of a physician
-Rapamycin acts by suppressing the master nutrient sensing protein mTOR [mechanistic target of Rapamycin]
02:45 Blagosklonny papers (Blagosklonny 2019)
05:23 Jane Mannick rapalogue paper (Mannick 2014)
08:04 Cardiomyopathy diagnosis : Apical hypertrophic cardiomyopathy
09:14 Elevated mTOR as common factor- Inflammation, fibrosis,
12:03 Rapamycin role to decrease mTOR overview common pathway
14:23 mTOR is essentially command and control of the cell for the last 2 billion years
15:00 Mitochondrial complex 1 affected by common pathway by rapamycin, caloric restriction, protein restriction, methionine restriction has universal anti-aging effects
16:05 Increased mTOR causes increased innate immune system/inflammation
17:28 2009 paper showed increased mouse lifespan not by just decreasing cancer but most other diseases of aging
19:15 Osteoarthritis inflammation improved by decreased mTOR and increased autophagy
23:00 Alzheimer disease as a disease of senescent cells
26:00 importance of dose timing for Rapamycin
27:00 Anti aging effects on mTOR1 and other effects on mTOR2
32:00 Rapamycin as off patent drug
37:00 Dosing considerations and subjective effects
40:00 Tracking HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) score
42:00 Improvement in exercise related to maximum cardiac output
45:00 Age associated cardiomyopathy
49:00 Untoward effects- Aphthous ulcers and decreased innate immune system. Be on guard for bacterial infections.
57:00 Personal lifestyle choices
https://rapamycintherapy.com/
Rapamycin Clinical Registry
https://www.rapamycin.io/
Bl

*** CONNECT WITH ROB ON SOCIAL MEDIA ( 300k++)***

Web: https://robertlufkinmd.com/
X:
https://x.com/robertlufkinmd
Youtube:
https://www.youtube.com/RobertLufkinMD
Instagram:
https://www.instagram.com/robertlufkinmd/
LinkedIn:
https://www.linkedin.com/in/robertlufkinmd/
Facebook:
https://www.facebook.com/robertlufkinmd
Threads:
https://www.threads.net/@robertlufkinmd

*** SPONSORSHIPS & BRANDS ***
We do work with sponsors and brands. If you are interested in working with us for your health industry product or service, please contact us at: https://www.robertlufkinmd.com/contact/
NOTE:
This is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have. Never disregard professional medical advice or delay in seeking it becaus...

  continue reading

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