EP 165: Harnessing CRISPR and RNA editing to transform healthcare with Dr. Ness Bermingham

The Genetics Podcast

0:00 Introduction

1:29 Ness’ journey to becoming an entrepreneur and first-time founder.

5:37 Discussing CRISPR Therapeutics and its application in treating sickle cell disease.

7:43 Exploring the potential of RNA therapies and Ness’ work at Korro Bio.

11:29 Balancing scientific discovery with commercial viability in alpha-1 antitrypsin therapies for lung and liver diseases.

14:55 Creating a vision, setting realistic goals, and managing capital in early-stage biotech companies.

19:42 Differentiating biotech companies that use the same platform technologies, such as RNA editing.

24:19 Addressing regulatory barriers in drug development and exploring phenotypic manifestations of diseases.

28:53 Discussing bottlenecks in biotechnology, including drug delivery, regulation, patient segregation, and reimbursement.

33:02 Exploring how to price cures based on the financial burden saved by the healthcare system.

35:31 Sharing insights on Khosla Ventures’ investment in OpenAI and the impact of AI in biotech.

41:28 Discussing the role of AI in identifying drug targets, increasing impact rates, and enhancing patient safety.

43:32 Introducing Ness’ podcast, Between the BioTech Waves.

46:23 Discovering what advancements in biotechnology Ness is most excited about.

51:40 Closing remarks.

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