Podcasts of the American Journal of Physiology-Gastrointestinal and Liver Physiology
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This series bridges the gap between research and patient care by providing medical oncologists and hematologists with ongoing access to the perspectives and opinions of national and international clinical investigators with expertise in gastrointestinal cancers.
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CancerCare's free Connect Education Workshops are a way for people to learn about cancer-related issues from the convenience of their home or office. Leading experts in oncology provide the most up-to-date information in these workshops to help you and your loved ones better understand and cope with your cancer diagnosis, treatment options, quality-of-life concerns, treatment side effects, pain management, doctor-patient communication and other important topics.
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The Implications of Recent Datasets for the Current and Future Management of Gastrointestinal Cancers — An ESMO Congress 2024 Review
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Dr Tanios Bekaii-Saab from Mayo Clinic in Phoenix, Arizona, and Dr Philip A Philip from the Henry Ford Cancer Institute in Detroit, Michigan, discuss recent research presentations on the treatment of gastrointestinal cancers.Autor: Neil Love, MD
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"Got Guts" The Micro Version: Electromechanical Coupling of the In-Vivo Pylorus
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Join coauthors Sam Simmonds, Ashton Matthee, and Timothy R. Angeli-Gordon as they delve into their recently published research, "Electromechanical Coupling and Anatomy of the In Vivo Gastroduodenal Junction." In this episode, they explore cutting-edge techniques like electrical mapping, impedance planimetry, and histological analysis to investigate…
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Practical Perspectives: Optimizing Diagnosis and Treatment for Patients with Desmoid Tumors
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Dr Thierry Alcindor from Dana-Farber Cancer Institute in Boston, Massachusetts, and Dr Mrinal Gounder from Memorial Sloan Kettering Cancer Center in New York, New York, summarize the treatment landscape for desmoid tumors and review novel options for targeted therapy.Autor: Neil Love, MD
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"Got Guts" The Micro Version: Effect of amniotic fluid on the esophageal epithelium
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Join coauthors Mark Rochman and Marc E. Rothenberg as they explore their recently published paper, "Amniotic Fluid Modifies Esophageal Epithelium Differentiation and Inflammatory Responses." In this engaging episode, they discuss how the interaction between amniotic fluid and the esophageal epithelium during pregnancy impacts epithelial differentia…
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"Got Guts" The Micro Version: The Effects of Simulated Gastroesophageal Reflux on Infant Pig Oropharyngeal Feeding Physiology
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Join coauthor Chloe Edmonds in this insightful episode as she delves into her recently published paper, "The Effects of Simulated Gastroesophageal Reflux on Infant Pig Oropharyngeal Feeding Physiology." Chloe explores how simulating gastroesophageal reflux in an infant pig model reveals significant alterations in pharyngeal swallowing dynamics. Dis…
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"Got Guts" The Micro Version: Autoimmune liver disease and hormonal responses
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In this episode, coauthors Anne-Sofie H. Jensen and Nicolai J. Wewer Albrechtsen discuss the recently published research titled "Patients with autoimmune liver disease have glucose disturbances that mechanistically differ from steatotic liver disease." The authors reveal that patients with autoimmune liver disease, even in the absence of overt diab…
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Caregiving for Your Loved One with Cancer
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- Definition of a Caregiver- What Research Tells Us About Caregivers’ Well Being- Caregiving for an Older Adult- Caregiving for a Younger Adult- Caregiving for a Friend- Caregivers for Cancer Survivors- Couples, Partners, Siblings & Friends- Family, Partner & Friend Communication- Care Coordination: Challenges & Tips- Stresses on Family, Partners &…
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Striving for Consensus: Optimizing the Current and Future Management of Biliary Tract Cancers
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Dr Lipika Goyal from Stanford Cancer Center in Palo Alto, California, Dr James J Harding from Memorial Sloan Kettering Cancer Center in New York, New York, Dr Milind Javle from The University of Texas MD Anderson Cancer Center in Houston, Texas, and Dr Robin K (Katie) Kelley from UCSF Helen Diller Family Comprehensive Cancer Center in San Francisco…
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Inside the Issue: Optimizing the Diagnosis and Treatment of Neuroendocrine Tumors
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Dr Pamela Kunz from the Yale School of Medicine and Yale Cancer Center in New Haven, Connecticut, and Dr Simron Singh from the Odette Cancer Centre and Sunnybrook Health Sciences Centre in Toronto, Ontario, Canada, discuss optimizing the diagnosis and treatment of neuroendocrine tumors.Autor: Neil Love, MD
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Inside the Issue: Integrating HER2-Targeted Strategies into the Management of Gastrointestinal Cancers
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Dr Tanios Bekaii-Saab from the Mayo Clinic Cancer Center in Phoenix, Arizona, and Dr John Strickler from Duke University in Durham, North Carolina, review clinical data supporting the application of HER2-targeted therapies for patients with gastrointestinal cancers.Autor: Neil Love, MD
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Oncology Today with Dr Neil Love: Optimizing the Management of Dedifferentiated Liposarcoma
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Dr Mrinal Gounder from Memorial Sloan Kettering Cancer Center in New York, New York, discusses recent updates on available and emerging treatment strategies for dedifferentiated liposarcoma and other sarcomas.Autor: Neil Love, MD
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Current Perspectives on Cancer Survivorship
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- Overview of Cancer Survivorship- Managing Post Treatment Side Effects/Late Effects- Quality-of-Life Concerns- Fear of Recurrence- Finding Your New Normal- The Importance of Treatment Summaries and Encounter Notes- Follow-Up with Your Oncologist and Primary Care Doctor, Including Discussion of Health Screening and Concerns- Guidelines to Prepare f…
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"Got Guts" The Micro Version: Inhibitory neurotransmission in the internal anal sphincter
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Coauthor Caroline A. Cobine dives into the fascinating world of internal anal sphincter biology in the latest episode of "Gut Guts." The research uncovers direct and indirect neural pathways that modulate intracellular calcium activity in interstitial cells of Cajal, shedding light on their role in smooth muscle cell function. Article Citation: Mod…
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"Got Guts" The Micro Version: Mechanical Stress-induced Connective Tissue Growth Factor and Intestinal Fibrosis
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In this episode of "Gut Guts" coauthor Xuan-Zheng Shi discusses new research on intestinal fibrosis in Crohn’s-like colitis. The study found that mechanical stress causes a protein called CTGF to increase, leading to fibrosis. In a rat model, easing the mechanical stress reduced connective tissue growth factor (CTGF) and lessened fibrosis. This sug…
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"Got Guts" The Micro Version: Characterization of Rat Gastric Slow Wave Activity
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Tune in to our latest podcast episode where Peng Du, Omkar N. Athavale, and Madeleine R. Di Natale dive into the fascinating world of gastric slow-wave conduction. They discuss their recent article titled "Mapping the rat gastric slow-wave conduction pathway: bridging in vitro and in vivo methods, revealing a loosely coupled region in the distal st…
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RTP Live from Chicago: Investigator Perspectives on Recent Advances and Challenging Questions in the Management of Colorectal Cancer
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Dr Scott Kopetz from The University of Texas MD Anderson Cancer Center in Houston, and Dr John Strickler from Duke University in Durham, North Carolina, discuss recent updates on available and novel treatment strategies for colorectal cancer.Autor: Neil Love, MD
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Current Perspectives on the Future of Cancer Research
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- Understanding the Future of Cancer Research & Clinical Trials- Increased Focus on Earlier Detection & Treatment of Cancer- Health Care Disparities Research- Enhanced Knowledge of the Molecular Portrait of Cancer- Artificial Intelligence (AI) Driven Approaches for Diagnosis & Treatment of Cancer- Microsatellite Instability (MSI): Mutations in DNA …
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"Got Guts" The Micro Version: Implicating the Cholecystokinin B Receptor in Liver Stem Cell Oncogenesis
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In this episode of "Got Guts" The Micro Version, Jill P. Smith highlights the recently published research titled "Implicating the cholecystokinin B receptor in liver stem cell oncogenesis." This investigation identified a novel pathway involving the activation of hepatic stem cells and liver oncogenesis. Receptor blockade or genetic disruption of t…
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How Health Care Disparities May Influence Your Cancer Treatment
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- Disproportionate Burden of COVID & Cancer on People of Color- Social Determinants of Health, Including Languages Spoken & Health Literacy- Influence of the Local & Regional Environment in Which You Live on Your Access to Oncology Care- Effect of COVID on Health Care Systems- How Race May Impact Your Access to Cancer Treatment, Management of Treat…
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What’s New in Precision Medicine
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- Understanding Precision Medicine: Overview & Value of Precision Medicine- How Precision Medicine is Different from Targeted Treatments?- Precision Medicine Role’s in Informing Treatment Decisions: Predicting Response to Treatment- The Role of Precision Medicine in Deciding the Treatment for Lung Cancer, Leukemia & Colon Cancer- Talking with Your …
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"Got Guts" The Micro Version: Corticotropin-Releasing Hormone Effects on Gastric Function
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In this podcast, I-Hsuan Huang highlights the recently published paper titled "Effects of corticotropin-releasing hormone on gastric electrical activity and sensorimotor function in healthy volunteers: a double-blinded crossover study." The aim of this research was to investigate the effects of peripheral corticotropin-releasing hormone infusion on…
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"Got Guts" The Micro Version: Effects of L. Casei-Fermented Milk on Mice with DSS Colitis
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Coauthors Mélanie G. Gareau and Maria L. Marco delve into the findings of their latest research titled "Milk and Lacticaseibacillus paracasei BL23 effects on intestinal responses in a murine model of colitis." This study marked the first exploration into sex-dependent responses to probiotic Lacticaseibacillus paracasei and milk, as well as the pote…
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Caring for Your Loved One with Cancer
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- Definition of a Caregiver- What Research Tells Us About Caregivers’ Well Being- Caregiving for an Older Adult- Caregiving for a Younger Adult- Couples, Partners, Siblings, & Friends- Challenges for Caregivers of Cancer Survivors- Family, Partner, & Friend Communication- Care Coordination Challenges & Tips- Stresses on Family, Partners, Friends, &…
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"Got Guts" The Micro Version: Characterize Mouse Glutamatergic Myenteric Neurons
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In this episode, Jia Liu and Bin Feng highlight the recently published research titled "Morphological, molecular, and functional characterization of mouse glutamatergic myenteric neurons." In this research, the authors reveal that VGLUT2-positive enteric neurons (EN), although constituting a small fraction of total EN, are homogeneously expressed i…
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Year in Review: Novel Treatments and Strategies in Gastroesophageal Cancer
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Prof Eric Van Cutsem from University Hospitals Leuven in Leuven, Belgium, discusses recent updates on available and novel treatment strategies for gastroesophageal cancer.Autor: Neil Love, MD
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Diverse Populations Participating in Decisions about Your Care
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- How Being a Member of Diverse Communities May Impact Your Access to Oncology Care, Treatment, Management of Treatment Side Effects & Pain Management- What to Expect from Your Relationship with Your Health Care Team: Is Your Health Care Team Providing You with Equitable, Excellent Care- What to Consider When Selecting a Cancer Care Team & Treatmen…
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Oncology Today with Dr Neil Love: Role of HER2-Directed Therapy in the Treatment of HER2-Expressing Gastrointestinal Cancers — Part 2 of a Special 3-Part Edition
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Dr Kanwal Raghav from The University of Texas MD Anderson Cancer Center in Houston discusses the role of HER2-directed therapy in the treatment of gastrointestinal tumors beyond gastroesophageal cancer.Autor: Neil Love, MD
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Managing Eye and Vision Changes Related to Cancer Treatments
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- Overview of Common Eye & Vision Changes Related to Cancer Treatments- Discussion of Common Eye & Vision Changes, Including Causes & Risk Factors- Tips to Manage Dry Eyes, Watery Eyes, Itching Eyes, Blepharitis, Loss of Eyelashes, Changes in Vision, Cataracts, Floaters, & Flashing Lights- The Role of the Multidisciplinary Team- Tips to Manage Low …
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Year in Review: Clinical Investigator Perspectives on the Most Relevant New Data Sets and Advances in Colorectal Cancer
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Professor Thierry André from the Hôpital Saint-Antoine in Paris, France, and Dr Arvind Dasari from MD Anderson Cancer Center in Houston, Texas, discuss recent developments regarding available and novel treatment strategies for colorectal cancer.Autor: Neil Love, MD
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Consensus or Controversy? Immune Checkpoint Inhibitors in the Management of Hepatobiliary Cancers — A 2024 Post-ASCO Gastrointestinal Cancers Symposium Review
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Dr Robin K (Katie) Kelley from the UCSF Helen Diller Family Comprehensive Cancer Center in San Francisco, California, and Dr Mark Yarchoan from the Johns Hopkins Sidney Kimmel Cancer Center in Baltimore, Maryland, discuss clinical decision-making with numerous treatment strategies for hepatocellular carcinoma and biliary tract cancers.…
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Advances in the Treatment of Gastric Cancer
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- Overview of Gastric Cancer, Including Diagnosis & Staging- Current Standard of Care, Including Chemotherapy- New Treatment Approaches & the Role of Targeted Treatment & Immunotherapy- Precision Medicine: Predicting Response to Treatment- The Role of Clinical Trials- How Research Contributes to Treatment Options- Controlling Treatment Side Effects…
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Year in Review: Clinical Investigator Perspectives on the Most Relevant New Data Sets and Advances in Gastroesophageal Cancers
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Dr Yelena Y Janjigian from Memorial Sloan Kettering Cancer Center in New York and Dr Zev Wainberg from UCLA Jonsson Comprehensive Cancer Center in Los Angeles discuss the management of gastroesophageal cancers and review emerging data sets in the field.Autor: Neil Love, MD
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”Got Guts” The Micro Version: Gastric Neuromuscular Transmission
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In this episode of the Got Guts podcast series Madeleine R. Di Natale of the University of Melbourne discusses the recently published manuscript titled "Characterization of neuromuscular transmission and projections of muscle motor neurons in the rat stomach." This study provides a detailed mapping of nerve transmission to the circular muscle of th…
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Understanding the Different Names for Biomarker Testing & Their Role in Selecting the Best Treatment for You
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- Overview of the Different Names for Biomarker Testing & Why They Can Be Helpful for Treatment- Tumor Marker Testing, Genomic Profiling, Genomic Sequencing, Molecular Profiling, Next Generation Sequencing- The Relationship Between Biomarker Testing & Precision Medicine- Types of Biomarker Tests for Cancer Treatment- Do I Need Biomarker Testing for…
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Consensus or Controversy? Investigator Perspectives on the Current and Future Role of Immune Checkpoint Inhibitors in the Management of Hepatobiliary Cancers
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Dr Ahmed Omar Kaseb from the University of Texas MD Anderson Cancer Center in Houston, Texas, and Prof Arndt Vogel from Schwartz Reisman Liver Research Centre in Toronto, Ontario, discuss the optimal selection and sequencing of checkpoint inhibitor therapy for patients with hepatobiliary cancers.Autor: Neil Love, MD
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”Got Guts” The Micro Version: Gene expression and microbiome composition in EsoCaSR-/-mice
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In this episode of the Got Guts Podcast series, Solange M. Abdulnour-Nakhoul of Tulane University, discusses the recently published manuscript titled "Alterations in gene expression and microbiome composition upon calcium sensing receptor deletion in the mouse esophagus." In this research Abdulnour-Nakhoul et al. highlight why calcium sensing recep…
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"Got Guts" Special Episode: The GI and Liver Section at the 2024 American Physiology Summit
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Listen as Editor in Chief of AJPGI and Liver Physiology, Mark Frey and the Chair of the Gastrointestinal & Liver Section, Pradeep Dudeja discuss what they are looking forward at the 2024 American Physiology Summit, April 4-7th. Registration Deadline for American Physiology Summit is March 11, 2024. Click here for more info on the American Journal o…
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Chemotherapy: Novel Approaches to Prevent and Manage Gastrointestinal Treatment Side Effects
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- Why Chemotherapy Causes Treatment Side Effects & Discomfort- Working with Your Healthcare Team to Better Understand & Cope with Potential Treatment Side Effects with a Plan to Manage or Prevent Them - Common Treatment Gastrointestinal (GI) Side Effects - You May Not Experience All of These - Loss of Appetite, Nausea, Vomiting, Mouth Sores, Stomat…
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Understanding the Important Role that Biomarker Testing Plays in Informing the Treatment of Cancer
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- Overview and Definition of Biomarkers- What Are Some Examples of Biomarker Testing- How Biomarker Testing Provides Useful Information for Cancer Treatment - Why the Molecular Portrait of Cancer Is So Important- The Role of the Pathologist- Benefits of Biomarker Testing & Precision Medicine- Predicting Response to Treatment- Clinical Trials: How R…
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Young Adult Survivorship: Fertility, Sexuality and Intimacy
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- Unique Needs of Young Adult Cancer Survivors- Identity, Relationships & Intimacy- Dating- Couples/Partners Dealing with Survivorship- Communicating about Sex- Sexuality & Intimacy- Sex Drive: Ability & Desire- Tips to Deal with Vaginal Dryness, Premature Menopause, Erectile Dysfunction, Premature Ejaculation & Sperm Banking- Low Desire: How to Ge…
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”Got Guts” The Micro Version: Pf Inhibits Inflammation-Induced Epithelial Break-Down
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In this episode Marine Mantel of Nantes Université discusses the recently published research in AJP-GI and Liver Physiology titled "Propionibacterium freudenreichii CIRM-BIA 129 mitigates colitis through S layer protein B-dependent epithelial strengthening." NEW & NOTEWORTHY Propionibacterium freudenreichii reduces dextran sodium sulfate (DSS)-indu…
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Addressing the LGBTQI+ Health Disparities Gap
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- Overview of Cancer & the LGBTQI+ Community, Including HIV & HPV- The LGBTQI+ Community’s Disproportionate Cancer Burden- Addressing the LGBTQI+ Health Disparities Gap, Including Mistrust of Health Care Providers- Barriers to Health Care Access, Including Discrimination- Health Care, Cancer Screening, Palliative and Supportive Care, Affordable Hou…
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”Got Guts” The Micro Version: IL-4Rα Signaling in Esophageal Smooth Muscle
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In this episode author, Melissa Nelson of Baylor University Medical Center, discusses the recently published manuscript titled "Th2 Cytokine Signaling through IL-4Rα Increases Eotaxin-3 Secretion and Tension in Human Esophageal Smooth Muscle." New and Noteworthy: Nelson et al. have found that Th2 cytokines increase eotaxin-3 secretion and tension i…
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Challenges Young Adults with Cancer Face: Coping Tips
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- Overview of Young Adults Living with Cancer, including Delays in Diagnosis- Where to Seek Cancer Treatment: Selecting Your Oncology Health Care Team, Including Young Adult Cancer Programs- The Importance of Treatment Summaries- Follow-Up with Your Oncologist & Primary Care Doctor- Managing Post Treatment Side Effects/Late Effects- Talking with th…
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Inside the Issue: Targeted and Immunotherapeutic Approaches for Biliary Tract Cancers
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Dr Lipika Goyal from The Stanford Cancer Center and Dr Milind Javle from The University of Texas MD Anderson Cancer Center in Houston discuss targeted and immunotherapeutic approaches for biliary tract cancers.Autor: Neil Love, MD
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”Got Guts” The Micro Version: Order of Events after Keratin 8 Sequential Downregulation
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In this podcast, authors Maria A. Ilomäki and Lauri Polari (both at Åbo Akademi University) discuss their recently published research titled “Defining a timeline of colon pathologies after keratin 8 loss: Rapid crypt elongation and diarrhea are followed by epithelial erosion and cell exfoliation.” New and Noteworthy: Understanding the order in whic…
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Meet The Professor: Optimizing the Management of Gastroesophageal Cancers — Part 3 of a 3-Part Series
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Dr Samuel J Klempner from Massachusetts General Hospital in Boston discusses optimizing the management of gastroesophageal cancers.Autor: Neil Love, MD
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”Got Guts” The Micro Version: Effects of in utero fluoxetine exposure on the GI tract
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In this episode authors Katherine L. Prowse,, and Elyanne M. Ratcliffe of McMaster University, discuss their recently published article titled “Effects of in utero exposure to fluoxetine on the gastrointestinal tract of rat offspring.” NEW & NOTEWORTHY There is increasing recognition of the relevance of in utero and early postnatal exposures in the…
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Current Perspectives on Cancer Survivorship
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- Overview of Cancer Survivorship, in the Context of COVID- Managing Post Treatment Side Effects/Late Effects- Quality-of-Life Concerns- Fear of Recurrence- Finding Your New Normal- The Importance of Treatment Summaries & Encounter Notes- Follow-Up with Your Oncologist & Primary Care Doctor, including Discussion of Health Screening & Concerns- Guid…
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”Got Guts” The Micro Version: Colon ion transporter gene expression during cirrhosis
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Diego Alvarez de la Rosa of the University of La Laguna discusses the recently published manuscript titled “Decaying kidney function during cirrhosis correlates with remodeling of distal colon aldosterone target gene expression.” NEW & NOTEWORTHY Liver cirrhosis progression significantly alters ion transporter subunit expression in the rat distal c…
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