Melding quantum mechanics with artificial intelligence is going to change how we understand our world. Several years ago, a small team was pursuing a deeper understanding of the quantum sciences while tracking advancements in machine intelligence. Combining two complex and misunderstood fields of study, Fernando Dominguez Pinuaga, Vice President, a…

Where is the money in oceanographic research? Fundamental understanding of the watery parts of our planet (i.e. most of it) is woefully under pursued. However, just as it seems some ocean systems are almost falling apart – coral bleaching, rising tides, species extinctions – we are beginning to see more attention paid to exploring the depths. "Ther…

It’s a bird, it’s a plane, it’s… technically a flying boat! When challenged to imagine how to electrify aviation, Billy Thalheimer, CEO and co-founder of REGENT Craft, and his team set to work looking at what has been done with hydroplanes before – and what emerging technologies are available today that change the equation for what is possible and …

The blue parts of our planet are beautiful yet stunningly punishing for even our toughest of technologies. Dark, crushing, unexplored, and unknown – the depths of the seas are where an explorer like Jeff Smith has devoted his career to understanding. As the Vice President and General Manager of Autonomous and Undersea Systems at Saab, Inc., Smith h…

Tough Tech Today is transitioning seasons, recapping our Season 3 themes exploring the tough tech domains of biology, space, and fusion energy. We are also preparing for the show's fourth season and we are really excited for it! Upcoming themes: Blue tech – The advanced technologies of the maritime industry. Incredible machines, sustainable oceans,…

If this company perfectly combines lasers and atoms, the reaction could be worth trillions of dollars. Focused Energy’s Thomas Forner, CEO, and Pravesh Patel, CTO, join us to talk about making lasers. Lots and lots of lasers. But for what aim? They are pointing hundreds of directed beams at a tiny target: a millimeter-sized plastic capsule of deute…

Investors are betting big on clean energy becoming the norm. Tina Tosukhowong of TDK Ventures joins us for a review of the major approaches to curbing carbon emissions in hard-to-abate industries. A thorough assessment led Tosukhowong to opportunities for practical, grid-scale fusion. TDK Ventures invested in Type One Energy Group, a private fusion…

How do we harness the power of the stars to deliver clean energy on Earth? It has been a collective goal – and, perhaps, an impending imperative – for human civilization to secure renewable energy sources for its present and future needs. The team at Proxima Fusion (https://www.proximafusion.com/about), led by co-founder and CEO Francesco Sciortino…

Standing up a space force within the world’s largest bureaucracy is not for the faint of heart. Preston Dunlap – former (and first) Chief Architect / Chief Technology Officer of the United States Air Force and Space Force and present CEO of Arkenstone Ventures – has developed a privileged view into the government machinations necessary to design, d…

An early-stage startup will offer unparalleled weather data when it unfolds its orbital sensors. Captivated by the stars and focused on improving life on Earth, Mithril Technologies founder and CEO, Scarlett Koller, is venturing into weather awareness and storm tracking by launching and commercializing a large space-based sensor. In this episode, w…

In one sentence: The space economy is booming in more ways than one. Space-based assets are changing the way industries operate on Earth. Chad Anderson – Founder and Managing Partner at Space Capital – is one of those individuals who has a deep perspective on the what it is like backing the entrepreneurs who are launching the newest breed of space …

In one sentence... The interactions of the microbial world within us has been incredibly difficult to see – until now. From the depths of our intestines to the surface of our skin, our bodies are host to trillions of microbial cells spanning thousands of species. While critical to helping us to fend off illnesses and digest complex foods, we know v…

In one sentence... Aging is malleable and there is a particular, mysterious protein of interest that may enable new therapies for age-related diseases such as stroke, diabetes, and obesity. Young blood in old bodies has been demonstrated in several studies to counteract some age-correlated ailments. Mark Allen, a medical doctor by training and an e…

In one sentence... Computational biology is enhancing our understanding of intrinsically disordered proteins, leading to exciting new medical treatments. Overview From videogames to protein discovery, high performance computing impacts how we understand and engage with each other and the world around us. Virginia Burger, CEO and Co-Founder of New E…

Join a tag-up among JMill and Forrest as we reveal something really exciting for what’s ahead: the launch of the newest season of Tough Tech Today! Plus, we mention work and babies. We set the stage for our new monthly cadence, with a new release occurring on the second Tuesday of each month. Each quarter (3 months), we focus on a theme. The next t…

Digitization of the physical world brings new synergies and expanding attack surfaces – so it is key to invest in those who defend us. ————— Overview: Probing the cybersecurity of 3D printing, scaling the digital transformation of manufacturing, and developing quantum-safe encryption for the next evolution of the Internet, Matt Goldstein, Managing …

In one sentence: “Synthesizing” and “food” are uncommon word pairings, but the engineered dishes they serve may be an appetizing feast for the senses. Overview: Climate change, a growing global population, and maturation of new biotechnologies are driving the motivation for – and means of – producing more food. Engineering is improving traditional …

In one sentence: We can make cancer cells tell us exactly where they are. ————— Overview: Consumer internet entrepreneurs lack many of the skills for the life sciences revolution – or do they? Cyriac Roeding, CEO and co-founder of Earli, shows us what his team of bioengineers are accomplishing by applying fast-learning software development discipli…

Just a quick Tough Tech Today update as we take a bye week and prepare for our guest in two weeks.Autor: Jonathan Miller and Forrest Meyen

In one sentence: When the frontiers of geology overlap with the frontlines of contested regions, international collaborations help protect minerals core to our civilization. ————— Overview: There’s a world of minerals in every electronic device. Anything that cannot be grown must be mined, Emily King tells us. A global mining expert and founder of …

In one sentence: Unlocking new mRNA treatments will save lives, but it's not as simple as that. ————— Overview ————— Jake Becraft of Strand Therapeutics is an expert in designing and programming mRNA, critical strands of genetic material that provide instructions for making proteins. As one suite of tools in the emerging synthetic biology toolkit, …

In one sentence: A needle shaped like a hockey puck is a ‘revolutionary’ medical device that can deliver epinephrine during a severe allergic reaction on Earth or in space. ————— Overview ————— EpiPens and other emergency auto-injectors have changed little for decades, though there are known limitations in their accidental (mis)use. Conor Cullinane…

A chat to review the first year of Tough Tech Today.Autor: Jonathan Miller and Forrest Meyen

In one sentence... Human health upgrades may be unlocked by a data storage expert focused on probing the proteome. Overview: It’s not everyday that one hears about the crucial relationship between digital data storage and biology, yet this is core to Sujal Patel’s work leading Nautilus Biotechnology. By any measure already an accomplished tech entr…

In one sentence... Living on the Moon requires infrastructure that Justin Cyrus of Lunar Outpost knows can be helpful here on Earth. Overview Earth’s moon is viewed as the upcoming base of operations for humanity’s further exploration of the cosmos. Justin Cyrus, founder of Lunar Outpost, shares what it is like building a suite of technologies that…

Banshees of the United States Air Force hunt for mission-enhancing technologies. The world's largest startup accelerator, MassChallenge, teamed up with the Air Force Labs to establish the Banshees training program. Members are U.S. Department of Defense acquisitions officers who are learning how to find tough tech and nurture dual-use ventures. Suc…

In one sentence... A helicopter rescue mission gone awry fuels this man’s mission to bring heroes home safely with drones built for aircraft load stabilization. Overview As a Black Hawk helicopter’s rotors whop-whop-whopped overhead in their fight for command of the winds amid a stormy – and ultimately failed – rescue mission, a teenage Caleb Carr …

He built a mass spectrometer from scratch and reinvented it in the process! Bearing a smile, Mazdak “Maz” Taghioskoui says he immigrated to the United States from Iran for a good education and same-day shipping, two key features that have supported his focus on building – from scratch – a sophisticated next-generation analytical tool: the Trace Mat…

While aboard a plane nosediving into Baghdad, one may be forgiven for pondering how one’s life path could lead from vacuum cleaners to minesweeping robots. Yet, not only does Orin Hoffman, of MIT’s The Engine venture capital firm, share this humbling connection, but also how it advances an overarching narrative of the United States national industr…

What happens to the ideas generated across the United States federal government’s research initiatives? Will Dickson and Trinity Torres walk us through the pathways of taxpayer-funded technological advancements and opportunities for a diverse pool of private citizens-entrepreneurs to find commercial success licensing patents owned by the U.S. gover…

Dual-use ventures – tough tech startups pursuing commercial relationships with the private sector and federal government, are a unique class of companies with whom Kathryn "Katy" Person, of the MIT Innovation Initiative, works daily. "[Working with the United States government, such as the Department of Defense,] is not for everyone and not for eve…

No longer the domain of strictly nation-states, 'new space' is undergoing a wave of commercialization and growth. Two key engineering challenges, observed Louis Perna, are in-space communications and propulsion. He and his co-founder, Natalya Bailey, launched Accion Systems to provide cost-effective electrospray propulsion for satellites. While the…

The building blocks of life, deoxyribonucleic acid (DNA), can be used for computational advantage, posits Dr. James Banal, postdoctoral research associate at the Massachusetts Institute of Technology (MIT), Department of Biological Engineering, in the Bathe Lab. “I work on the wackiest things in computing and storage right now, which is quantum com…