Investigating Innovative Cardiovascular Research at the Intersection of Academic Theory and Clinical Practice. Podcasts are also available on most podcast services including Apple, Google and Pocket Cast
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Coronary Inflammation Imaging with FAI Score on CT angiography with Prof. Stefan Neubauer
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Send us a Text Message. Prof. Stefan Neubauer and Dr. Thomas Nero discuss two recent papers on the utility of coronary inflammation imaging on CT coronary angiography with Fat Attenuation Index (FAI)FAI score. The ORFAN study demonstrated a 20 fold increased risk in CV event rates with low vs high FAI score and a 10 fold increased event rate in pat…
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Trial Statistics, Trial Design and AI with Dr. C Michael Gibson
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34:28
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34:28
Send us a Text Message. Dr Gibson and Dr Nero discuss the oft maligned issue of medical statistics. Their discussion covers the pros and cons of traditional Cox proportional hazards regression models and Kaplan-Meier curves and newer techniques including win ratios. They then dip their toes into AI. A great overview by one of our leading clinical t…
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Deep Dive into Lp(a) with Dr Steven Nissen Part 2 of 2
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Send us a Text Message. This episode is a deep dive into Lipoprotein a with Dr Steven Nissen from the Cleveland Clinic. He and Dr Nero discuss the genetics of Lp(a), its pathophysiology, current treatment strategies and research into lowering Lp(a) levels. This is a fascinating conversation that also discusses the role of coronary inflammation in t…
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Lp(a): a basic clinical approach with Dr. Steven Nissen Part 1 of 2
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Send us a Text Message. Dr Steven Nissen from the Cleveland Clinic discuses with Dr. Thomas Nero the basic clinical approach to Lp(a) with need for routine testing and a few simple case studies. In the second (longer podcast) they take a deep deep dive into Lp(a) genetic, pathophysiology and the current research trials.…
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Coronary Artery Disease in the Endurance Athlete with Dr Aaron Baggish
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Send us a Text Message. Dr Thomas Nero speaks with Dr Aaron Baggish about coronary artery disease in the endurance athlete (and non-athlete as well!) They discuss cardiovascular testing in Masters athletes including ETT, coronary calcium scoring and CT angiography as well as risk factor identification, inflammation, physical & emotional stress and …
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Atrial Fibrillation and Clinical Trials with Dr John Mandrola
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48:30
Send us a Text Message. Dr Mandrola discusses recent trail data with Dr. Thomas Nero including the results from Artesia, NOAH Afnet 6, Frail AF, Azalea and Oceanic-AF. They also discuss Left Atrial Appendage Occlusion and utility of wearable devices. Finally, a shout out to Dr. Andre Foy and his work on multi-morbidity and its role in clinical tria…
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Coronary Calcium Score and CT Coronary Angiography with Dr. Mathew Budoff
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Send us a Text Message. Dr. Thomas Nero speaks with Dr. Mathew Budoff about Coronary Calcium Scoring, CT Coronary Angiography and cardiovascular outcomes. The discussion goes beyond basic risk factor enhancement, highlighting its role to help evaluate disease progression, power future clinical trials and determine efficacy of therapy. Along the way…
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Dr Elizabeth Ofili and The African American Heart Study
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Send us a Text Message. Dr. Elizabeth Ofili discusses the African American Heart Study with Dr. Thomas Nero. They also discuss her work at the NIH and the African American Heart Failure Trial and the role of community based pragmatic clinical trials.Autor: Thomas Nero MD FACC
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Anticoagulation, Thombin Generation and Factor XI inhibition in ACS and Atrial Fibrillation with Dr C. Michael Gibson
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Send us a Text Message. Dr. Thomas Nero discusses current therapy with Factor X inhibitors, the new research with Factor XI inhibition and specifically the enrolling Milvexian clinical trials with Dr. C Micahel Gibson. In addition they discuss, the addition of these medications along wiht anti-platelet therapy, Lp(a) and other interesting current a…
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Diabetes and Cardiovascular Disease, SGLT2 inhibitors and GLP1 receptor agonists with Dr. Peter Toth
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Send us a Text Message. Dr. Thomas Nero speaks with Dr Peter Toth about the dramatic change occuring in diabtetes management and its effect on cardiovascular disease. Starting with the biochemestry of diabetes and its effects at the cellular level, the discussion goes on to speak about the role SGLT2 inhibitors and GLP1 receptor agonists play in DM…
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Lipids, Lipid Sub-fractionations and Inflammation, Putting It All Together with Dr Peter Toth
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Send us a Text Message. Dr. Thomas Nero speaks with Dr. Peter Toth about the complex biology of lipids and atherosclerosis. In this episode Dr Toth dives into LDL goals, therapies for attenuating non-LDL risk, vascular biology and the where are research studies lead us in choosing therapies.Autor: Thomas Nero MD FACC
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Inflammation and Coronary Artery Disease with Dr Paul Ridker
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40:52
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40:52
Send us a Text Message. Dr Paul Ridker discusses his paper on residual inflammatory risk that was recently published in the Lancet with Dr. Thomas Nero. He discusses the pathology of inflammation as part of atherosclerosis, utilization of hs-CRP in clinical trials and in daily practice as well as current therapeutic options and ongoing investigatio…
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Pragmatic Clinical Trials and EVOLVE-MI with Dr Christopher Cannon
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Send us a Text Message. Dr Christopher Cannon discusses the potential of Pragmatic Clinical Trials in our research armamentarium with Dr. Thomas Nero. They review the EVOLVE-MI trial for Early use of Evolocumab after Myocardial Infarction in detail and highlight the potential for future research.Autor: Thomas Nero MD FACC
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Spontaneous Coronary Artery Dissection (SCAD) with Dr. Sharonne Hayes Part 1
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Send us a Text Message. Dr Sharonne Hayes of the May Clinic discusses SCAD with Dr. Thomas Nero. Initially focusing on the new treatment paradigms, their wide ranging discussion covers etiology, pathophysiology and potential future therapeutic options. Tis is the first of a two part podcast.Autor: Thomas Nero MD FACC
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Spontaneous Coronary Artery Dissection (SCAD) with Dr. Sharonne Hayes Part 2
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Send us a Text Message. Dr Sharoanne Hayes and Dr. Thomas Nero continue their discussion of SCAD focusing on genetics, trial design and the role of online registries as well as the holistic treatment of the SCAD patient. This is part two of two.Autor: Thomas Nero MD FACC
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Evaluation of Coronary Inflammation with CT angiography and Fat Attenuation Indexing
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Send us a Text Message. Dr. Nero discusses evaluation of coronary artery disease and coronary inflammaiton with Dr. Cheerag Shirodaria from the University of Oxford. Dr. Shirodaria along with Prof. Charalambos Antonidies at Caristo Diagnostics have developed a ground breaking technology that allows us to evaluate not just the severity of a coronary…
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Legal Aspects of FDA approval and implications for clinical research
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Send us a Text Message. Prof. Christine Coughlin of Wake Forest School of Law speaks with Dr. Thomas Nero on the FDA approval process, emergency use authorization, Right to Try Legislation and the implications for clinical research, diversity and health care equity. Prof. Coughlin holds positions in the College of Medicine as well as the Law school…
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Coronary Artery Disease in the Athlete with Dr Paul Thompson
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Send us a Text Message. Although exercise usually provides a cardiovascular benefit, there is some data that points to an increase in event rates in extreme endurance athletes. In this episode, Dr. Thomas Nero and Dr. Paul Thompson discuss the surprising findings regarding coronary calcium, cardiac troponins and atrial fibrillation in the endurance…
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Statin Associated Muscle Symptoms with Dr Thomas Nero and Dr Paul Thompson
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22:41
Send us a Text Message. Dr Nero and Dr Thomposn discuss Statin Associated Muscle Symptoms (SAMS) and the results of the STOMP and SAMSON trials. In addition, they discuss statins and athletic training, options for the statin intolerant patient and research regarding further investigation of the ranitadine receptor among other topics…
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CAD, Lipid Sub-fractionation and Lp(a) with Dr Paul Thompson
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Send us a Text Message. Our inaugural podcast is a discussion between Dr. Paul Thompson, Chief of Cardiology, Emeritus, at Hartford Hospital and Professor of Medicine, Emeritus, at University of Connecticut and Dr. Thomas Nero, Director of Cardiovascular Research at CAFC about coronary artery disease, lipid sub-fractionation and the role of lipopro…
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Send us a Text Message. I’m Dr Thomas Nero. At Future Pulse our goal is to investigate the future of cardiovascular research and promote that discussion. What is the next step and how will this trickle down to our clinical practice? What’s exciting and new in our field and why should we be interested. We will also look at the other side of the equa…
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