Week 10 College Football Picks, DFS Lineup Tips: FSU vs. UNC, Ohio State at Penn State, Duke at Miami, Oregon at Michigan, Florida vs. Georgia, Texas A&M at South Carolina, Louisville at Clemson, Pitt at SMU and more

Everything Noles: For Florida State Seminoles Fans

No. 4 Ohio State Buckeyes (-3.5) at No. 3 Penn State Nittany Lions, Noon ET, FOX

Ohio State being favored here is surprising; I expected it closer to a pick-em. Both teams are contenders but feel one step from disappointment. In a close matchup like this, taking the home team with points seems smart.

Pick: Penn State +3.5

Duke Blue Devils (+20.5) at No. 5 Miami Hurricanes, Noon ET, ABC

A big spread, but Duke is still Duke. Coach Manny Diaz is motivated to win, but Miami’s talent gap is clear. I’ll take Duke plus 20 points.

Pick: Duke +20.5

No. 1 Oregon Ducks (-15.5) at Michigan Wolverines, 3:30 p.m. ET, CBS

Michigan’s struggles are evident, and Oregon looks title-bound. While Michigan’s defense is solid, Oregon’s firepower on both sides likely proves too much.

Pick: Oregon -15.5

Florida Gators (+16.5) vs. No. 2 Georgia Bulldogs, 3:30 p.m. ET, ABC

Florida has turned things around after a rough start and could still reach bowl eligibility. Freshman QB DJ Lagway offers high potential, but Georgia’s strength will likely overpower them.

Pick: Georgia -16.5

Texas Tech Red Raiders (+14.5) at No. 11 Iowa State Cyclones, 3:30 p.m. ET, ESPN

Could this be the year Matt Campbell makes a CFP push? Despite Iowa State’s Big 12 co-favorite status, I’m skeptical of their Cinderella story and will take Texas Tech with the points.

Pick: Texas Tech +14.5

No. 13 Indiana Hoosiers (-7.5) at Michigan State Spartans, 3:30 p.m. ET, Peacock

Indiana is optimistic about QB Kurtis Rourke’s return and will try to keep their momentum going. I think they’ll pull off a win over Michigan State.

Pick: Michigan State +7.5

North Carolina Tar Heels (-2.5) at Florida State Seminoles, 3:30 p.m. ET, ACCN

Here’s the game for those still following.

Pick: Florida State +2.5

No. 10 Texas A&M Aggies (-2.5) at South Carolina Gamecocks, 7:30 p.m. ET, ABC

Texas A&M’s playoff path looks clear, but South Carolina’s unpredictability could pose a challenge. After a rough start, A&M rallied, but South Carolina’s home advantage may keep it close.

Pick: South Carolina +2.5

Louisville Cardinals (+10.5) at No. 11 Clemson Tigers, 7:30 p.m. ET, ESPN

Clemson feels vulnerable, and while Louisville may not hand them a loss, they could expose some weaknesses.

Pick: Louisville +10.5

No. 18 Pitt Panthers (+7.5) at SMU Mustangs, 8:00 p.m. ET, ACCN

Sticking with Pitt, even without recent game experience.

Pick: Pitt +7.5

DK Saturday Main Slate DFS Picks

Record Year to Date: 18 Wins 20 Ties 16 Losses

Quarterback

Rocco Becht, Iowa State ($6,500) – Becht is an under-the-radar play, leading Iowa State to a top-10 rank. Though they focus on the run, Becht’s rushing and passing skills make him a strong pick against Texas Tech’s weak defense, which allows almost 34 points per game.

Bryson Daily, Army ($9,200) – Service academy QBs like Daily have high ceilings. Facing Air Force, who struggles against the run, Daily is set for a big game with potential help from Kanye Udoh.

Running Back

Trevor Etienne, Georgia ($6,500) – Etienne’s recent performance makes him a top pick in Georgia’s depleted backfield. With Florida’s weak run defense, Etienne should see increased carries as Georgia likely pulls away.

Mario Anderson, Memphis ($7,800) – Anderson thrives in Memphis’s high-paced offense and faces a UTSA defense that’s struggled against competent run teams. There’s some risk of Memphis relying on the pass, but Anderson’s volume makes him valuable.

Wide Receiver

Tez Johnson, Oregon ($7,700) – Johnson’s high target count and Oregon’s offensive strength make him a strong play. Michigan’s secondary struggles, and Johnson’s consistent performances offer a solid floor and ceiling.

Chris Carpenter, UTSA ($3,700) – With WR1 McCuin out, Carpenter has been heavily targeted and is a great value in this high-scoring game.

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