3 of 3 SARS-CoV-2 Spike Protein, CD8+ T cells and Long COVID

Heliox: Where Evidence Meets Empathy

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Welcome to the Heliox Podcast, where we unravel the mysteries of medical science together. On today's fascinating episode, we're diving into two groundbreaking studies that might help us understand the puzzle of long COVID. We'll explore how the virus's spike protein could affect blood clotting through an unexpected mechanism, and we'll look at how our immune system's memory cells behave over time in long COVID patients. What's particularly exciting is how these findings could explain some persistent symptoms and point to the continued importance of vaccination. Join us for a journey into the molecular world of COVID-19, where we're finally beginning to connect some crucial dots in this complex medical mystery.
The S1 protein of SARS-CoV-2 can induce the formation of amyloid fibrils, which are associated with micro clots.

Amyloidogenesis of SARS-CoV-2 Spike Protein
https://pubs.acs.org/doi/10.1021/jacs.2c03925

SARS-CoV-2-specific CD8+ T cells from people with long COVID establish and maintain effector phenotype and key TCR signatures over 2 years https://www.pnas.org/doi/10.1073/pnas.2411428121

See Also:
Mast Cell Activation Episode
https://www.buzzsprout.com/2405788/episodes/15875307
Understanding Long COVID Through CD8+ T Cell Responses
https://www.buzzsprout.com/2405788/episodes/15952636
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