Molecular mechanism of inflammasome activation & onset & progression of type 2 diabetes

Genefitletics

Type 2 diabetes is a global epidemic with the number of people developing this disease is going to increase by 40% by the end of the year 2023. In India alone 100 million + people are dealing with this metabolic syndrome. We have seen a number of companies claiming they can reverse diabetes just by tracking blood sugar & Hba1c levels through CGM machines. However, there is a huge gap in understanding metabolic dysfunction. Suppressing blood sugar level is not equal to reversal of diabetes. Let us understand diabetes- Pre-diabetes/Type 2 diabetes is the last stage of metabolic syndrome. This disease starts developing around 15 to 20 years ago. Interaction between your microbiome & food substates creates a condition of gut dysbiosis where in first fasting insulin spikes, then fasting glucose spikes & finally Hba1c spikes. The focus has to prevent fasting insulin from spiking at first place If your blood glucose level is elevated, it means damage has already been done & your insulin sensitivity is falling. In such a situation, reversing diabetes is a distant dream. Please do not fall for such obnoxious claims We really need to understand molecular interactions & risk taking place which has not been reflected in Blood glucose & Hba1c levels. Type 2 diabetes is caused by low grade chronic inflammation which is the outcome of overactive immune response. The interaction between gut microbiome & food can lead to production of harmful metabolites which can make your immune system become alert & trigger biochemical responses- which can be inflammatory response, immune response or blood clotting response. However, immune cells need help on how to respond. This is where role of inflammasomes comes in Inflammasomes are innate immune system receptors which activate enzymes that produce pro-inflammatory cytokines in response to harmful stuff released by microbes that makes immune system trigger inflammation In case of Diabetes, NLRP3 inflammasomes triggers secretion of IL-1Beta & IL-18 cytokines which reduces insulin sensitivity We at Genefitetics assesses molecular risk of fasting insulin spike which has not been reflected in blood glucose/Hba1c levels & through our unique postprandial glycemic response prediction model can inform you if a particular food is going to spike your insulin even before you consume it. This model would be part of UP THE GUT, VAGECO & soon to be launched ORAHYG solution Our today’s talk discusses this in detail