Off-the-Shelf Scalable Cell Therapies to Cure Cancer, HIV, and More: Dr. Marco Alessandrini, Antion Biosciences

X-Health.show - meet the future of healthcare

If you heard about miraculous CAR-T cell therapies that cure cancer in one go, my guest today works on something one step further: immunotherapies that are manufactured from healthy donor cells. That means a thousand cancer patients may receive in the future a life-saving shot manufactured ahead and administered when needed.
You may expect

• a fascinating journey into off-the-shelf cell immune therapies of the future
• how the HIV virus works and how understanding this is key to the novel therapy
• the difference between gene editing and gene engineering
• what is gene silencing
• what is microRNA
• and how to administer immune cells from a donor without creating immunowars

Dr. Marco Alessandrini is the CEO of Antion Biosciences. A biochemist and molecular biologist who aims to democratize access to mind-boggling (and very expensive now) cell therapies. A seasoned researcher who beautifully talks about gene and cell engineering.
Antion Biosciences is a Swiss biotech startup developing novel gene and gene-modified therapies thanks to a proprietary multiplex cell engineering platform. Their miCAR T cells are manufactured – hold your breath – from a healthy donor to treat a thousand cancer patients. They are at the beginning of this very promising journey.
https://antionbio.com

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The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

Rozdziały

1. Dr. Marco Alessandrini and Antion Biosciences (00:00:00)

2. Donor Cell Therapies for Haematological Cancer Patients: T-Cell Malignancies (00:01:24)

3. What Are Cell Therapies, Gene-Modified Cell Therapies, Gene Therapies (00:03:09)

4. The Kiss-And-Kill Effect of T-Cells, CAR-T Cells (00:07:22)

5. The Limits of Autologous Cell Therapies (00:13:39)

6. Off-the-Shelf Allogenic Cell Therapies: How to Engineer T-Cells (00:16:18)

7. How HIV Virus Works (00:21:18)

8. What is MicroRNA and How to Use It (00:25:51)

9. Why to Suppress Genes in Cell and Gene Therapies (00:31:01)

10. The Berlin Patient – the Only Person Cured of HIV, and Gene Suppressing (00:36:34)

11. Transitioning from Academia to Biotech (00:44:42)

12. Researching and Improving MicroRNA Technology for Many Other Diseases and Conditions (00:49:01)

13. Thank You, Follow Antion Biosciences (00:53:34)

14. Follow X-Health.show, Disclaimer (00:54:45)