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In each episode, host Dr. Irena O’Brien explains the science-based insights behind a particular concept and interviews a coach to discuss how these apply in the real world. Irena “un-complicates” neuroscience and teaches practical evidence-based tools and strategies that listeners can use in their coaching practices.
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Work Beyond Mac

Jason Cipriani

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For many, Apple’s iPad is more than just a tablet, it’s a tool that has, in some cases, completely replaced the laptop. Each episode of Work Beyond Mac will feature guests who’ve made the switch from a traditional computer over to the iPad. We’ll take a look at the apps, accessories and services that have made the transition possible, as well as dive into the tasks that may still require a Mac or PC to complete. If you’d like to be a guest, have suggestions or want to talk all things iPad, p ...
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Exploring all things genetics. Dr Patrick Short, University of Cambridge alumnus and CEO of Sano Genetics, analyses the science, interviews the experts, and discusses the latest findings and breakthroughs in genetic research. To find out more about Sano Genetics and its mission to accelerate the future of precision medicine visit: www.sanogenetics.com
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The Reputation Matters podcast will feature business owners and marketers to talk all about reputation management - the good and the bad. We’ll talk all about the obvious, and not so obvious, strategies people can use to improve the online reputation. We’ll also share examples of businesses that have done a great job of managing their reputation, and some that haven’t, so you can learn more about how and why to keep the reputation of your business in great shape.
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Lon 01:51 Lon’s involvement in the very first GWAS and what drew him to large-scale genomics research 03:32 Was moving away from candidate genes towards GWAS and data sharing initially a controversial idea? 05:25 What Lon believes has driven collaboration and data sharing within research communiti…
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Ever insightful, Ally Machate emphasizes embracing personal definitions of success and the acceptance of fear in writing. She shares strategies for overcoming “comparison-itis” and leveraging rejection to build resilience, all while maintaining a unique contribution to the literary world. In each episode of Neuroscience of Coaching, host Dr. Irena …
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01:15 - Introductions 02:02 - How our understanding of the non-coding genome has evolved throughout Nadav’s career 04:56 - Our current understanding of non-coding genome grammar 07:40 - Is there a missing piece to the common variant, common disease paradigm? 10:25 - Introducing ultraconserved elements (UCEs) and human accelerated regions (HARs) 12:…
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Marco 02:00 The areas Marco focused on during his academic career and what motivated him to found his first company 03:18 How our understanding of ageing has changed over the past two decades and some of the current big questions in ageing biology 06:01 How to get a clearer picture of the ageing p…
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As an expert in mastermind groups, Jay Fairbrother deeply understands the components and complexities of peer learning. In each episode of Neuroscience of Coaching, host Dr. Irena O’Brien explains the science-based insights behind a particular concept and interviews a coach to discuss how these apply in the real world. Just as she does in her profe…
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Martin 01:35 How a particularly large Indian meal resulted in a book about intermittent fasting and the biology of ageing 05:10 The biological mechanisms behind intermittent fasting, and whether it’s been established to extend life expectancy in humans. 10:13 What we know (and what we don’t) about…
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Tony 02:00 What Tony was expecting going into the role of CEO at UK Biocentre, and how the COVID-19 pandemic changed his plans 03:38 Receiving a phone call from the UK government in March 2020 asking the UK Biocentre to stop all of its projects and focus on sequencing COVID-19 samples 05:12 The UK…
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Business coach Krista Martin takes a systematic approach to solid growth that places emphasis on strong decision-making. She advocates for swift action over excessive research, urging listeners to embrace imperfection, minimize decision fatigue, and focus on evolving skills as your business grows. In each episode of Neuroscience of Coaching, host D…
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0:00 Intro 2:00 Mike’s career prior to the Million Veteran Program (MVP), how Mike got to work on MVP, and important milestones in the project's evolution 8:30 Future goals for the Million Veteran Program in expanding and diversifying the research cohort 11:00 The roles of various omics in advancing the project's development 14:30 The most meaningf…
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Scott 01:55 Scott’s career highlights to date, ranging from epidemiology to the genetics of asthma and chronic obstructive pulmonary disease (COPD) 04:56 How and why Scott decided to transition into genetics 06:30 The advances in our understanding of the genetics of asthma and COPD over the past 2…
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Dr. Irena is joined by Anke Herrmann to discuss the importance of downtime for reducing stress and improving productivity. Clients often feel guilty taking time off, but breaks lead to better sleep, health, and work output. Likewise, downtime is crucial for the insights that propel success. In each episode of Neuroscience of Coaching, host Dr. Iren…
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Austin 01:42 What is aging and how should we think about it? 03:50 Discussion of Austin’s recent breakthrough paper on aging, including the questions he set out to answer, and the outcomes of the research 06:32 How Austin’s work focuses on using large-scale population proteomics data to create acc…
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Dr. Irena and Melanie Benson discuss imposter syndrome — feeling like a fraud despite being competent and achieving success. It’s driven by past experiences that lower self-worth and encourage perfectionism. And although the predictive brain fuels imposter syndrome, it can also help overcome it. In each episode of Neuroscience of Coaching, host Dr.…
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Daniel 02:04 Defining rare disease in the age of personalized medicine 04:57 Key touchpoints with the Medicines and Healthcare products Regulatory Agency (MHRA) when developing a new medicine 09:27 Improvements over the course of Daniel’s career when it comes to incentivizing and making the path t…
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0:00 Introduction 1:40 A recurrent de novo mutation in a noncoding region of a small nucleolar RNA gene that has been identified as one of the most common causes of neurodevelopmental disorders This pathogenic variant escaped notice for years because it was not located in a protein coding region of the genome It now shows potential as a target for …
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In this insightful episode, Dov Gordon stresses the value of creating simple processes and sticking to them, while Dr. Irena highlights that willpower can be built by regularly pushing yourself slightly beyond your comfort zones. Consistent, incremental improvement is crucial for long-term success. In each episode of Neuroscience of Coaching, host …
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Jakob and background on Pheiron 02:14 What made Jakob decide to start Pheiron, what the company does, and how his scientific background inspired him to found a start-up 5:24 Jakob’s excitement and inspiration around the power and potential of machine learning 07:07 Cardiology and heart failure as …
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0:00 Introduction 1:40 Andrea’s background and how she got into the field of genetics, neuroimaging, and metabolic disorders 4:00 Insights into Andrea’s clinical practice, including the diverse families and patients she serves and her approach to clinical decision-making 6:30 How genetics and genomics have changed the diagnostic journey in the last…
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Dr. Irena is joined by Jason Moss to discuss the widely touted technique of visualization. The two explore the line between what people think visualization is and what actually happens in the mind, while clarifying the roles of fantasy versus expectation and process versus outcome. In each episode of Neuroscience of Coaching, host Dr. Irena O’Brien…
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Lori Orlando 03:00 Lori’s career: From mathematical modelling to genetics and family history 05:11 The study that revealed 20% of the general population is at a higher risk of disease than average and needs preventative care 07:36 The first five diseases that Lori started analysing through informa…
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0:00 Intro to The Genetics Podcast 1:00 Welcome to Ben Goldacre 02:22 Ben’s open data projects at the Bennett Institute and the challenges they aim to tackle 04:03 Using Electronic Health Records (EHR) to help the National Health Service improve care 06:18 The importance of software development within healthcare data and how to manage salary scales…
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This episode digs into the fear of public speaking with guest Jon Schumacher. Drawing from his marketing background, he emphasizes authenticity and intentional practice, reveals tactics to master anxiety and truly connect with audiences, and reveals how imperfections can elevate performance. In each episode of Neuroscience of Coaching, host Dr. Ire…
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0:00 Intro to The Genetics Podcast. 01:00 Welcome to Michelle. 02:00 Sstop codon diseases and how are they characterised 03:45 Diseases caused by premature stop codons in haploinsufficient genes. 04:35 The role of transfer RNA technology in finding solutions for premature stop codon diseases. 06:16 How Alltrna is engineering tRNAs which can bind to…
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Kay Adams and Deborah Ross reveal the magic of journaling, merging neuroscience and therapeutic writing. Through their profound insights, discover how reflective practices can foster self-awareness, harness neuroplasticity, and become powerful tools for manifesting a desired life. In each episode of Neuroscience of Coaching, host Dr. Irena O’Brien …
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0:00 Introduction 1:45 Almut’s research experience, including two recent publications on genome-scale metabolic reconstruction human microorganisms Genome-scale metabolic reconstruction of 7,302 human microorganisms for personalized medicine APOLLO: A genome-scale metabolic reconstruction resource of 247,092 diverse human microbes spanning multiple…
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0:00 Intro 1:30 Mavis’ career arc, from starting as a midwife to researching medical innovation and technology with an emphasis on advocacy and equity 7:00 Systemic issues that are easily overlooked in medical research and advancements Webinar: Participant Diversity: Increasing the Impact of Biomedical Research Webinar 10:00 Addressing Eurocentrici…
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0:00 Introduction 2:00 Allison’s personal journey to researching epilepsy and ring chromosome 20 syndrome 4:00 Biggest challenges families face with ring chromosome 20 syndrome 11:00 Incidence and prevalence of r(20) syndrome, and how we can improve data reliability 21:00 Applying next generation sequencing to r(20) syndrome gene research 29:00 Eng…
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Executive coach Sharon Richmond joins Dr. Irena O’Brien to explore the fascinating concept of team flow—a state of peak performance from all members of a team, characterized by effortless work and the activation of alpha waves in the brain. Discover how micromanaging can obstruct team flow and damage workplace dynamics, while fostering a shared goa…
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0:00 Introduction 1:30 Ingrid’s initial interests in genetics, paediatrics, and newborn screening 2:45 How the original BabySeq project, a pioneering newborn sequencing program got started, how it’s going, and the launch of BabySeq2 8:45 Lessons from BabySeq1 and goals for BabySeq2 10:30 Potential societal and long-term considerations for those inv…
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0:00 Introduction 1:00 The backstory of how Kira first started DNA Today in 2012, when she was still in high school! 3:30 Some of Kira’s favourite topics she has discussed on DNA Today, including the legacy of Henrietta Lacks, and the story of a Glee actress with down syndrome 10:00 Kira’s best practices for podcasting, from over 10 years of experi…
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Today, we explore the fascinating world of neuroplasticity with guest Marisa Murray, a leadership development expert. We’ll unpack the ways this phenomenon plays a crucial role in personal development, which will enrich your understanding of how neuroscience can revolutionize your coaching practice. You’ll learn about the brain’s ability to change …
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0:00 Introduction 2:00 The value of an English Literature degree in designing and analysing research studies in medicine 3:45 Emma’s entrance to pharmacogenomics and her transition from practising physician to genetics research 6:00 How the East London Genes and Health program is increasing representation of diverse populations, namely South Asians…
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0:00 Introduction 1:00 George’s upcoming big projects, including developing full recycling, renewing energy, creating bioweather maps, and harnessing citizen science 6:45 Progress in engineering viral resistance in humans, including thoughts from pre- and post- pandemic 11:00 A swapped genetic code that prevents viral infections and gene transfer b…
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Welcome to Neuroscience of Coaching. In each episode, host Dr. Irena O’Brien explains the science-based insights behind a particular concept and interviews a coach to discuss how these apply in the real world. Just as she does in her professional programs, Irena “un-complicates” neuroscience and teaches practical evidence-based tools and strategies…
  continue reading
 
0:00 Intro 0:40 Jake’s experiences as a serial entrepreneur starting five companies with a basis in genomic science 5:30 Opportunities for research and drug development in the realm of somatic science 9:20 Somatic evolution and how it provides valuable insights into disease mechanisms 12:30 Advantages and disadvantages of studying germline genome-w…
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Lenore Skenazy is the accidental pioneer of the “free-range kids movement” and literally wrote the book on the subject. Following that, she co-founded Let Grow, a nonprofit promoting childhood independence and resilience. “The real problem is that our culture has insisted that adults always be supervising kids.” — Lenore Skenazy After her newspaper…
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Show Notes: 0:00 Introduction 1:20 How polydactyl mutations can inform research on non-coding variant mechanisms The importance of low-affinity binding between transcription factors and targets How these lessons can help us improve our understanding of drug and target discovery See Veera’s January round-up for more information: https://www.gwasstor…
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Welcome to Neuroscience of Coaching. In each episode, host Dr. Irena O’Brien explains the science-based insights behind a particular concept and interviews a coach to discuss how these apply in the real world. Just as she does in her professional programs, Irena “un-complicates” neuroscience and teaches practical evidence-based tools and strategies…
  continue reading
 
Lion Goodman is a Professional Certified Coach and the CEO of the Clear Beliefs Institute. “I understand beliefs to be the infrastructure of the human mind.”— Lion Goodman Lion Goodman has been called a subconscious-pattern detective, a belief therapist, a healer of the psyche, a teacher of change agents, a coach of coaches, and an “evocateur” — on…
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0:00 Introduction 0:45 Jean’s personal experiences with family members with genetic ALS 10:00 Jean’s thoughts on the barriers and facilitators to providing treatment for those with genetic ALS 13:20 Insights into C9orf72, a common genetic determinant of ALS, and how it can also be associated with FTD 16:10 Jean’s experiences as an active advocate f…
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0:00 Introduction 1:05 Insights into the PD GENEration’s (a programme from the Parkinson's Foundation) milestones and progress points for the upcoming year 3:30 The shifting attitudes and perspectives of neurologists and healthcare workers at the PD GENEration 5:50 Insights into Nacho’s work with the genetics of Parkinson’s disease 10:20 Barriers a…
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Welcome to Neuroscience of Coaching. In each episode, host Dr. Irena O’Brien explains the science-based insights behind a particular concept and interviews a coach to discuss how these apply in the real world. Just as she does in her professional programs, Irena “un-complicates” neuroscience and teaches practical evidence-based tools and strategies…
  continue reading
 
0:00 Intro 0:25 Mazen’s lifelong commitment to furthering the field of precision medicine in liver disease research, fueled by a personal connection of his grandmother developing MASH cirrhosis 2:30 Breakthroughs in the field of metabolic dysfunction-associated steatotic liver disease (MASLD) since the beginning of Mazen’s career 5:30 The potential…
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0:00 Introduction 0:25 Julia’s personal experience with ultra-rare diseases within her family 10:25 The importance of increasing accessibility to genetic testing across populations to learn more about ultra-rare diseases 14:00 The origin story of Rare Trait Hope Fund 23:50 Current research and next steps in developing potential gene therapies for a…
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Welcome to Neuroscience of Coaching. In each episode, host Dr. Irena O’Brien explains the science-based insights behind a particular concept and interviews a coach to discuss how these apply in the real world. Just as she does in her professional programs, Irena “un-complicates” neuroscience and teaches practical evidence-based tools and strategies…
  continue reading
 
0:00 Introduction 1:25 How Lord O’Shaughnessy became involved in scientific policy making and his path to writing the UK Commercial Clinical Trials Review. 04:05 How Lord O’Shaughnessy pivoted from education to a focus on life sciences 06:38 The biggest challenges Lord O’Shaughnessy faced during his time as Parliamentary Under Secretary for Health …
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0:00 Introduction 01:10 How growing up in Malawi planted the seeds for John’s career in medicine and transition to therapeutic development 04:35 Why John focuses on rare diseases and conditions such as asthma 06:01 What has changed over the last decade in terms of treating and understanding asthma and the progress that genetics has enabled 07:31 Wh…
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Welcome to Neuroscience of Coaching. In each episode, host Dr. Irena O’Brien explains the science-based insights behind a particular concept and interviews a coach to discuss how these apply in the real world. Just as she does in her professional programs, Irena “un-complicates” neuroscience and teaches practical evidence-based tools and strategies…
  continue reading
 
Welcome to Neuroscience of Coaching. In each episode, host Dr. Irena O’Brien explains the science-based insights behind a particular concept, and interviews a coach to discuss how these apply in the real world. Just as she does in her professional programs, Irena “un-complicates” neuroscience and teaches practical, evidence-based tools and strategi…
  continue reading
 
Welcome to Neuroscience of Coaching. In each episode, host Dr. Irena O’Brien explains the science-based insights behind a particular concept, and interviews a coach to discuss how these apply in the real world. Just as she does in her professional programs, Irena “un-complicates” neuroscience and teaches practical, evidence-based tools and strategi…
  continue reading
 
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