Episode 38: Gerald Commissiong and Dr Dorit Arad - Tollovid

TLC Sessions - Living with Long Covid

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Cloud Realities

1
CR093: Role of AI/Gen AI in cybersecurity with Corence Klop, Rabobank 44:18

16 dni temu44:18

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44:18

AI and Generative AI are transforming cybersecurity by enhancing threat detection and response. These technologies offer unmatched accuracy and efficiency, making them crucial for protecting sensitive data. As cyber threats evolve, integrating AI into security strategies is essential. This week, Dave, Esmee and Rob talk to Corence Klop, CISO at the Rabobank, about the expanding role of AI and Generative AI in cybersecurity, and how to begin integrating these technologies into your organization. TLDR 04:45 Rob is confused about wrong AI information for a hotel booking 08:20 Conversation with Corence 33:40 How can you identify the state of flow for your end-user in agile practices? 40:50 Going to the swimming pool and disco with your daughter Guest Corence Klop: https://www.linkedin.com/in/corenceklop/ Hosts Dave Chapman: https://www.linkedin.com/in/chapmandr/ Esmee van de Giessen: https://www.linkedin.com/in/esmeevandegiessen/ Rob Kernahan: https://www.linkedin.com/in/rob-kernahan/ Production Marcel van der Burg: https://www.linkedin.com/in/marcel-vd-burg/ Dave Chapman: https://www.linkedin.com/in/chapmandr/ Sound Ben Corbett: https://www.linkedin.com/in/ben-corbett-3b6a11135/ Louis Corbett: https://www.linkedin.com/in/louis-corbett-087250264/ ' Cloud Realities' is an original podcast from Capgemini…

3 lata temu 57:07

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The Long Covid space has been abuzz with talk of Tollovid - the dietary supplement that is claimed to act, in much the same way as Paxlovid, on inhibiting 3CL protease. We wanted to get some clear answers on how this supplement works, the potential benefits, and its safety profile. We spoke to CEO of Todos Medical, Gerald Commissiong, who has brought this product to market, and Dr Dorit Arad, a biochemist and drug developer who has engineered Tollovid from her 28 years working in the field of protease inhibition in viruses. They were both keen to impress that this is a supplement and not a drug - they do not claim to prevent, treat, or cure Long Covid with Tollovid - but they suggest that there is anecdotal evidence that it helps.

Living with Long Covid? How was your week?
Website - https://www.tlcsessions.net/
Twitter - @SessionsTlc https://twitter.com/sessionstlc
Insta - @tlcsessions https://www.instagram.com/tlcsessions

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#Fitness #TLC Sessions #Science #Biology #Medicine #Long Covid #Longcovid #Post-covid #Pasc #On Covid19 #Viruses #Immune #Symptoms #Inflammation

Episode 38: Gerald Commissiong and Dr Dorit Arad - Tollovid

TLC Sessions - Living with Long Covid

31 subscribers

published 3 lata temu

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Living with Long Covid? How was your week?
Website - https://www.tlcsessions.net/
Twitter - @SessionsTlc https://twitter.com/sessionstlc
Insta - @tlcsessions https://www.instagram.com/tlcsessions

82 odcinków

#Fitness #TLC Sessions #Science #Biology #Medicine #Long Covid #Longcovid #Post-covid #Pasc #On Covid19 #Viruses #Immune #Symptoms #Inflammation

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TLC Sessions - Living with Long Covid

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Episode 78: Benjamin Krishna - Interferon Gamma 1:02:41

39 weeks temu1:02:41

1:02:41

Dr Benjamin Krishna and the Virology & Immunology team at Cambridge University have identified a protein, elevated in the blood of Long Covid patients, that could act as a potential biomarker for the condition. This week, we spoke to Dr Krishna about their study, published in Science , which sampled the blood of Long Covid patients across several years. They found Interferon Gamma (IFNɣ) at, an average of, six times the normal level. IFNɣ is a key protein in the body’s immune response, a moderator of inflammation and a mediator for fighting infection. These raised levels of IFNɣ are indicative of the immune system remaining active throughout Long Covid. The team found that levels returned to normal in patients once they recovered from the disease. These findings could help develop treatment strategies and offer a clear diagnosis for some Long Covid patients. Living with Long Covid? How was your week? Website - https://www.tlcsessions.net/ Twitter - @SessionsTlc https://twitter.com/sessionstlc Insta - @tlcsessions https://www.instagram.com/tlcsessions…

TLC Sessions - Living with Long Covid

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Episode 77: Dr Theoharis Theoharides - The Mast Cell Master 1:08:04

44 weeks temu1:08:04

1:08:04

Dr Theoharis Theoharides , aka “The Mast Cell Master”, has been exploring the world of Mast Cells, their influence on our bodily functions, neurology and genetic make up, for over half a century. The Director of the Center of Excellence for Neuroinflammation Research and Professor at the Institute for Neuro-Immune Medicine at Nova Southeastern University joins us this week to discuss the role that Mast Cells play in neurological conditions such as Long Covid, and the way in which we influence and change our mast cells' behaviour with our infections, stress levels, trauma and activity. Living with Long Covid? How was your week? Website - https://www.tlcsessions.net/ Twitter - @SessionsTlc https://twitter.com/sessionstlc Insta - @tlcsessions https://www.instagram.com/tlcsessions…

TLC Sessions - Living with Long Covid

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Episode 76: Conor Browne - biorisk consultant 1:05:05

46 weeks temu1:05:05

1:05:05

Conor Browne, an independent Biorisk Consultant, analyses biosecurity risks for governmental bodies, commercial enterprises and NGOs, aiding with business continuity, forecasting and policy. He understood that Covid-19 was airborne in February 2020 but, he says, “it’s the first message that sticks”. In this week’s episode he discusses how our governments’ initial messaging of handwashing and surface-to-surface transmission had a huge impact on the course of the pandemic. We talk about the need for clean air in mitigating the perpetual spread of Covid-19, and he highlights the ultimate risks, of Long Covid, Covid-related illness and the viral mutations that could leave us with an even heavier burden than anticipated. Living with Long Covid? How was your week? Website - https://www.tlcsessions.net/ Twitter - @SessionsTlc https://twitter.com/sessionstlc Insta - @tlcsessions https://www.instagram.com/tlcsessions…

TLC Sessions - Living with Long Covid

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Episode 75: Prof. David Cutler - the economics of Long Covid 49:07

49 weeks temu49:07

49:07

David Cutler , Professor of Applied Economics at Harvard University, has spent his career assessing the economics of healthcare. Over the past four years he has applied his skills to assessing the cost of Covid , and subsequently Long Covid, on the U.S. economy. His original analysis, published in JAMA in 2022 , suggested that Long Covid would cost the U.S. economy $2.6 trillion, but with the chronic condition proving more prevalent and prolonged than originally estimated, those figures were revised to a massive $3.7 trillion. In this week’s episode Cutler explains these costs and their implications. We discuss what has been included in projecting these staggering costs, and what needs to be done, on governmental and clinical levels, to manage these costs and the condition. Whilst the findings may seem bleak, it is Cutler’s hope that in highlighting the enormity of the problem, policymakers may see the urgent need to address it. Living with Long Covid? How was your week? Website - https://www.tlcsessions.net/ Twitter - @SessionsTlc https://twitter.com/sessionstlc Insta - @tlcsessions https://www.instagram.com/tlcsessions…

TLC Sessions - Living with Long Covid

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Episode 74: Nancy Klimas M.D. - Neuroimmunology 1:03:59

51 weeks temu1:03:59

1:03:59

Dr Nancy Klimas , Director of the Institute for Neuro-Immune Medicine, Nova Southeastern University, is an immunologist internationally renowned for her work in multi-symptom illnesses. In this week’s episode she explains her work, from HIV through ME/CFS and Gulf War Syndrome, that has led to her having insight and an amazing team to channel efforts into Long Covid research and treatment. In an insightful overview she describes her work in understanding the mechanisms (viral persistence, viral reactivation), impacts of (MCAS, cell dysfunction, T-cell dysregulation ) and potential alleviation of the disease. She has been involved in studies looking at clinical therapeutics such as LDN and has seen remarkable results with the use of MABs which she is hoping to replicate in a larger clinical trial in the coming weeks. Living with Long Covid? How was your week? Website - https://www.tlcsessions.net/ Twitter - @SessionsTlc https://twitter.com/sessionstlc Insta - @tlcsessions https://www.instagram.com/tlcsessions…

TLC Sessions - Living with Long Covid

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Episode 73: Dr Rob Wüst - Post-exertional Malaise (P.E.M) 44:44

1 year temu44:44

44:44

Dr Rob Wüst , Assistant Professor in the Faculty of Movement and Behaviour Sciences, is an expert cardiac and skeletal muscle metabolism and mitochondrial function. He and the team at Vrije Universiteit, Amsterdam, published the “PEM study” in Nature Communications , which investigated the muscular changes in Long Covid patients who experience post-exertional malaise (PEM), or “the worsening of fatigue- and pain-related symptoms after acute mental or physical exercise”. In this week’s episode Wüst talks us through the key findings of their study, including the muscular changes, mitochondrial dysfunction and microclots that were present in the Long Covid patients compared to their control group. He discusses the effects of bedrest on the human body and how exercise is usually beneficial for overall health, but highlights what was revealed through blood tests and muscle biopsies in their study – that Long Covid patients have limited exercise capacity with lower mitochondrial function and our rehabilitation needs to be handled with this unique understanding. Living with Long Covid? How was your week? Website - https://www.tlcsessions.net/ Twitter - @SessionsTlc https://twitter.com/sessionstlc Insta - @tlcsessions https://www.instagram.com/tlcsessions…

TLC Sessions - Living with Long Covid

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Episode 72: Dr Thomas Chelimsky - autonomic dysfunction, migraine and trauma 56:13

1 year temu56:13

56:13

Dr Thomas Chelimsky, Professor of Neurology and Director of VCU’s autonomic laboratory, is a specialist in autonomic dysfunction and a vocal advocate for considering the mind and body as one cohesive system. He, along with his team at the VCU clinic, take a unique brain-body approach to treating Long Covid patients, with success. In this week’s episode he discusses the autonomic issues faced by Long Covid patients including migraine, which he believes is prevalent in c. 50% of patients, and POTS which he discusses ‘almost never shows up alone’, linking it with the migraine, fibromyalgia and IBS (irritable bowel syndrome). He explains the roles of the periaqueductal gray region of the brain and the vagus nerve, alongside the implications of trauma (both physical and mental) on the autonomic system, and the role that it plays in Long Covid. Living with Long Covid? How was your week? Website - https://www.tlcsessions.net/ Twitter - @SessionsTlc https://twitter.com/sessionstlc Insta - @tlcsessions https://www.instagram.com/tlcsessions…

TLC Sessions - Living with Long Covid

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Episode 71: Dr Andrew Klein - Iron and B12 deficiency 1:05:26

1 year temu1:05:26

1:05:26

Dr Andrew Klein , an anaesthetist at the Royal Papworth Hospital Cambridge, runs the Cambridge Iron Clinic where he treats people with Iron and B12 deficiencies. Since the start of Covid he has seen an increase in people with these deficiencies, many of whom have been diagnosed with Long Covid. In this episode Dr Klein talks us through the overlapping symptom sets that render people debilitated with all three conditions. He describes the various ways in which are body is not able to uptake and store sufficient B12 and iron, the consequences of this, and the way in which they can be simply treated. And we discuss the data ranges used by the NHS to determine conditions and allocate treatment and once again draw the conclusion that correct care should only be determined by listening to the patient. Living with Long Covid? How was your week? Website - https://www.tlcsessions.net/ Twitter - @SessionsTlc https://twitter.com/sessionstlc Insta - @tlcsessions https://www.instagram.com/tlcsessions…

TLC Sessions - Living with Long Covid

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Episode 70: Benjamin Abramoff, M.D. – Serotonin Depletion 48:42

1 year temu48:42

48:42

Physiatrist Benjamin Abramoff, M.D. is the Director and Co-founder of the Post Covid Assessment and Recovery Clinic at the University of Pennsylvania, Philadelphia. An Assistant Professor in Physical Medicine and Rehabilition, Abramoff used his expertise to co-author the study, published in Cell , that found that serotonin depletion is prevalent in Long Covid patients. In this week’s episode, Abramoff talks us through the findings of their study, the hypothesis of what drives the depletion, the impacts that this has on the body, and preliminary ideas of what might help, both symptomatically and to address the root cause of the disease that seems to be viral persistance. Living with Long Covid? How was your week? Website - https://www.tlcsessions.net/ Twitter - @SessionsTlc https://twitter.com/sessionstlc Insta - @tlcsessions https://www.instagram.com/tlcsessions…

TLC Sessions - Living with Long Covid

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Episode 69: Prof. Tim Henrich - Viral persistence and T cell dysregulation 1:07:53

1 year temu1:07:53

1:07:53

Tim Henrich is a Professor of Medicine and expert in infectious diseases, focused on chronic viral infections at the University of California, San Francisco. He is another member of the titan Long Covid research team who have tracked patients since the beginning of the pandemic (LIINC study) and are making roads into understanding the mechanism of the disease and potentials for treating it. In this week’s episode he talks us through some of the exciting work that he is doing, alongside our previous guests Steven Deeks & Michael Peluso. Using a combination of longitudinal studies, biopsies and high resolution PET / CT imaging, the team have established changes to t cells throughout the bodies of Long Covid patients, and found evidence of viral persistence. They are currently conducting multiple clinical trials including monoclonal antibodies to act on viral reservoirs, and the anti-viral Ensitrelvir which has undergone several trials in active SARS-COV2 previously, and believe that they are getting to grips with the pathophysiology of the disease. Living with Long Covid? How was your week? Website - https://www.tlcsessions.net/ Twitter - @SessionsTlc https://twitter.com/sessionstlc Insta - @tlcsessions https://www.instagram.com/tlcsessions…

TLC Sessions - Living with Long Covid

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LC Supplement to Episode 68 - Anxiety and Depression 3:56

1 year temu3:56

3:56

A supplement to Episode 68 - Consultant Neurologist Steven Allder of Re:Cognition Health discusses the way that injury to the brain causes anxiety and depression in Traumatic Brain Injury and could explain some of the mental health impact of Long Covid. Living with Long Covid? How was your week? Website - https://www.tlcsessions.net/ Twitter - @SessionsTlc https://twitter.com/sessionstlc Insta - @tlcsessions https://www.instagram.com/tlcsessions…

TLC Sessions - Living with Long Covid

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LC Supplement to Episode 68 - Tinnitus 5:04

1 year temu5:04

5:04

A supplement to Episode 68 - Consultant Neurologist Steven Allder of Re:Cognition Health explains what tinnitus is and why we are experiencing it in Long Covid. Living with Long Covid? How was your week? Website - https://www.tlcsessions.net/ Twitter - @SessionsTlc https://twitter.com/sessionstlc Insta - @tlcsessions https://www.instagram.com/tlcsessions…

TLC Sessions - Living with Long Covid

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Episode 68: Dr Steven Allder - Re:Cognition Health 53:57

1 year temu53:57

53:57

Consultant Neurologist Steven Allder of R e:Cognition Health has applied his wealth of experience investigating Traumatic Brain Injury (TBI) and Functional Neurological Disorder (FND) to understanding the impact of Long Covid on the brain. In this week’s conversation we discuss inflammation of the brain of Long Covid patients which is visible using PET imaging; Allder believes this inflammation could be driving the neurological symptoms, and beyond, in a similar way to the impact of a blow to the head observing numerous similarities to TBI; we discuss polyvagal nerve theory; and Allder explains the way in which it takes more than just cold, hard evidence to persuade the scientific community. And following up on our previous episode , Dr Allder is working with Prof. Andrew Shaw at Attomarker, believing that Long Covid may be driven by viral persistence and that establishing a patient’s antibody gap, using the Attomarker testing, could enable us to remove viral residue with tailored antibody treatment. Living with Long Covid? How was your week? Website - https://www.tlcsessions.net/ Twitter - @SessionsTlc https://twitter.com/sessionstlc Insta - @tlcsessions https://www.instagram.com/tlcsessions…

TLC Sessions - Living with Long Covid

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Episode 67: Prof. Andrew Shaw – Antibody gap 1:00:36

1 year temu1:00:36

1:00:36

Professor Andrew Shaw, University of Exeter, believes that he has devised a diagnostic test for Long Covid. His company, Attomarker , have developed a test which can reveal a gap in a patient’s antibody spectrum – their response to acute SARS-COV2 from a finger prick of blood. This gap, he says, has lead to a viral residue that causes the chronic symptoms of Long Covid. Their hypothesis is that the gap can then be filled, either with monoclonal antibodies, or with an appropriate vaccine, to rid the patient of the disease. In this week’s episode we explore the theories of antibody response to the strains of Covid, the effects of the vaccine, the results that the Attomarker test and treatment which is being offered by Re:Cognition Health have so far yielded. Living with Long Covid? How was your week? Website - https://www.tlcsessions.net/ Twitter - @SessionsTlc https://twitter.com/sessionstlc Insta - @tlcsessions https://www.instagram.com/tlcsessions…

TLC Sessions - Living with Long Covid

1
Episode 66: Prof. Danny Altmann Returns 48:33

1 year temu48:33

48:33

Imperial College Professor of Immunology, Danny Altmann recently published “The immunology of long COVID” , a fantastically comprehensive overview in Nature Reviews Immunology. In this week’s episode Altmann, to whom we first spoke in the summer of 2021, talks us through some of the highlights of the work he's reviewed - serotonin depletion, gut biopsy findings, anti-virals, monoclonal antibodies and T cell depletion, along with his impression of a wide range of issues facing Long Covid sufferers, doctors and researchers – the state of patient care, vaccines, and the lack of funding for large scale studies and trials. Living with Long Covid? How was your week? Website - https://www.tlcsessions.net/ Twitter - @SessionsTlc https://twitter.com/sessionstlc Insta - @tlcsessions https://www.instagram.com/tlcsessions…

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